The Value Of Serum Golgi Glycoprotein 73 In Diagnosis And Grading Of Liver Cirrhosis

Objective: To study and compare the relationship between serum GP73,liver function index and cirrhosis,explore the value of serum GP73 in the diagnosis of cirrhosis,and analyze the relationship between serum GP73 and Child-Pugh classification of liver function in patients with cirrhosis.Methods: The clinical data of 150 patients with liver cirrhosis and 150 healthy people who visited the Affiliated Sanming First Hospital of Fujian Medical University from May 2016 to June 2019 were retrospectively analyzed,including: gender,age,GP73,ALB,ALT,AST,ALP,GGT,PT and PLT.The Child-Pugh score was used to evaluate the liver function.The differences between cirrhosis group and healthy control group were compared,and the related factors affecting cirrhosis were analyzed.The value of serum GP73 in the diagnosis of liver cirrhosis was evaluated by ROC curve analysis,and the quantitative relationship between liver cirrhosis and GP73 was further verified by Logistic regression analysis.To analyze the correlation between serum GP73 and Child-Pugh score of liver function and other serological indexes reflecting the severity of liver disease.To compare the differences among Child-Pugh A,B and C subgroups of liver function in patients with cirrhosis,and to evaluate the relationship between serum GP73 level and liver function grading in patients with cirrhosis.Results: 1.Compared with the control group,the serum GP73 level and AST,ALT,ALP,GGT and PT levels in the cirrhosis group were higher,while ALB and PLT levels were lower.There was significant statistical difference between the two groups(p <0.001).2.By drawing the ROC curve,the area under the curve of serum GP73 in the diagnosis of liver cirrhosis was 0.823(p < 0.0001),and the optimal cutoff value was135 ng/ml.The sensitivity was 60.00 %,and the specificity was 88.67 %.According to the optimal cutoff value of serum GP73,the serum GP73 was converted from the measurement data to the enumeration data,and further verified by Logistic regression analysis.It was concluded that serum GP73 > 135 ng/ml was an independent risk factor for the diagnosis of liver cirrhosis(β = 2.463,OR = 11.735,95%CI: 6.432-21.411,p <0.001).3.There was a positive correlation between serum GP73 and Child-Pugh score of liver function(r = 0.461,p < 0.001).Serum GP73 was positively correlated with ALP(r = 0.362,p < 0.001),GGT(r = 0.283,p < 0.001),AST(r = 0.406,p < 0.001)and ALT(r = 0.178,p < 0.05).It was negatively correlated with PLT(r =-0.478,p < 0.001).By comparing the liver function of Child-Pugh A,B and C subgroups in the liver cirrhosis group,it was found that the difference in serum GP73 between the groups was statistically significant(p < 0.001).Further the pairwise comparison of GP73 between subgroups,it was concluded that there was a statistically significant difference between A and B(p < 0.05),and there was also a statistically significant difference between A and C(p < 0.001),while there was no statistically significant difference between B and C(p > 0.05).It was also found that there was no significant difference in gender,age,ALP,ALT,PLT and GGT between subgroups(p > 0.05).Conclusion: Serum GP73 level was significantly increased in patients with liver cirrhosis.When serum GP73 > 135 ng/ml,the risk of liver cirrhosis increased by about12 times.