Correlation Analysis Between Respiratory Pathogens And TCM Syndromes In Children With Non-bacterial Pneumonia In Fangzhuang District, Beijing

Objective:To investigate the pathogenicity of respiratory and Chinese Medicine syndromes of children with non-bacterial pneumonia in Fangzhuang area of Beijing by analyzing the pathogenicity of pathogens and the types of Chinese Medicine syndromes in children with nonbacterial pneumonia.Methods:A total of 240 patientsaged between 3 and 18 years old with non-bacterial pneumonia were diagnosed in the pediatric outpatient department and ward in our hospital from January 2015 to December 2016.The data were collected from the clinical records.Indirect immunofluorescence assay(IIF)was used to detect respiratory pathogens and Enzyme-linkedimmunosorbent assay(ELASA)was used to detect the titer of MP Ig-M antibody.And the Chinese medicine syndrome differentiation would be accomplished after the classification of the patient at once.Results:We detected one or more pathogens in 137 of these children,with a positive rate of 57.08%.The total detection rate of IVB was the highest(36.25%,87/240),followed by MP(28.33%,68/240).and the single IVB infection rate was 29.20%(40/137)and the single MP infection rate was about 24.82%(34/137).137 cases of positive results included 55 cases of multiple pathogens(pathogen type ≥ 2)mixed infection,mixed infection accounted for about 22.92%of the total number(55/240),in the positive cases accounted for about 79.56%(40.15/137),of which IVA,IVB mixed infection is the most common,accounting for 19.27%of mixed infection,and MP mixed with other pathogens(more than one pathogen species)infection rate of 30.28%.There was no significant difference in the detection rate of the pathogens in children with different ages(P>0.05).The detection rate of IVA,IVB,RSV,ADV and CP was not correlated with the age of children,and the detection rate of PIV and MP was related to the age of children.The detection rate of Mycoplasma pneumoniae in 7 to 16 years old Higher than 3 to 6 years old.The total detection rate of respiratory pathogens did not differ in seasonal distribution(P>0.05),and the highest detection rate was 65%in winter.ELASA to detect Mycoplasma pneumoniae antibody titer ≥ 1:40 of 124 cases,the detection rate of 51.67%.There was no correlation between the detection rate of pathogens and the distribution of TCM syndromes(P>0.05).TCM syndromes were mainly phlegm-heat closure syndrome(75.83%),followed by wind-heat syndrome,no difference in seasonal distribution.There was a significant difference between the IIF method and the ELASA method in detecting the positive rate of Mycoplasma pneumoniae(P<0·01),the difference was statistically significant,the Kappa value was 0.236.The positive rate of ELASA detection was higher than that of ⅡF.Conclusion:From January 2015 to December 2016,children with non-bacterial pneumonia in Fangzhuang area of Beijing were mainly infected with IVB and MP,Mixed infection rate is high,RSV,ADV,CP infection is rare;Mycoplasma pneumoniae infection more common in the elderly;respiratory tract infection may be no significant correlation with the season,different viral pathogens can occur throughout the year,clinical treatment should be To be taken seriously.Chinese medicine syndromes to phlegm-heat closure of the main lung syndrome,followed by wind-heat closure of the lung syndrome;TCM syndrome in the course of the distribution of significant differences in the early stages of the disease can be seen cold syndrome,wind-heat closure of the lung syndrome;Significant seasonal distribution differences.There was no significant correlation between respiratory tract pathogen infection and distribution of TCM syndromes.