Effect Of Target Controlled Infusion Of Rocuronium On Muscle Relaxation Effect In LC Patients

Objective:To observe the effect of target controlled infusion of rocuronium on muscle relaxation effect in LC patients.Methods:Sixty patients who had underwent selective LC under general anesthesia between February to May of 2017 in our hospital were randomly divided into intermittent intravenous rocuronium group(RI group,n=30),induced by anesthesia at a concentration of 0.6 mg(2ED95)within 6s to end the injection,and target controlled infusion group(RT group,n=30),induced by anesthesia at a concentration of 3.0μg/ml(Ce).Both groups were performed with trachea cannula at T1=0,and the rocuronium Ce of RT group was set 0.1μg/ml.When T_l was up to 10%,RI group was injected 0.15 mg rocuronium and RT group was regulated by increasing or decreasing 0.1μg/ml Ce,then recorded intraoperative muscle relaxation index.Results:MAP and HR during intubation were significantly different in the two groups(P<0.05).The onset of muscle relaxant in RT group was longer than that in RI group(P<0.05).The total dosage of rocuronium in anesthesia maintenance period was lower in RT group than that in RI group(P<0.05),while the recovery time of muscle relaxation group was lower than that in RI group(P<0.05).There was no significant difference in the incidence of postoperative muscle relaxant between the two groups(P<0.05).Conclusion:(1)Targeted infusion of rocuronium is not suitable for induction of anesthesia,but is suitable for the maintenance of anesthesia in LC patients.(2)Under the same muscle relaxation condition,target controlled infusion saves rocuronium,avoids wasting medicine and resumes quickly after stopping the medicine,thus avoiding the complications caused by muscle relaxants.