| Objective :Objective: Graves disease(GD),also known as toxic diffuse goiter,is an organ-specific autoimmune disease with increased secretion of thyroid hormones.The incidence of Graves disease(GD)is gradually increasing,and the incidence rate is 1%-2%.The severity of the symptoms and signs of hyperthyroidism is closely related to the length of the patient’s history,the degree of hormone elevation,and the patient’s emotional condition.With the deepening of people’s research on the treatment of GD by Chinese medicine,the advantages of Chinese medicine in preventing and treating GD have gradually become apparent.This article aims to observe the effect of Huangqi Jiawei Fang combined with methimazole on the symptoms of GD and the improvement of thyroid function,and provide new ideas for the treatment of this disease with integrated Chinese and Western medicine.Methods:60 cases of Graves disease diagnosed and diagnosed in Hubei Provincial Traditional Chinese Medical Hospital Department of Endocrinology from January 2016 to September 2017 were selected.According to the syndrome differentiation and classification of TCM syndrome,the syndrome of Qi and yin deficiency and phlegm coagulating type are all syndrome differentiation.All patients were treated with conventional antithyroid drugs.60 patients were randomly divided into experimental group and control group by random number table.The control group was treated with hyperthyroidism.Be methimazole(10mg/)2 times / day,1 / times,Leucogen Tablets(20mg/)3 times / day,1 tablets each time.The drug dose is adjusted at any time according to the thyroid function,granulocyte result and heart rate.The experimental group added: tutor experience on the basis of the control group(Astragalus,Ophiopogon,Ligustrum lucidum,Lycium barbarum,dried lotus,bupleurum,Paeonia lactiflora,Poria,Fritillaria thunbergii,cat’s claw grass,hive,etc.),unified concentrated decoction to 200 ml,two times a day.The two groups were continuous Medication for 12 weeks.Before and after treatment were compared between the two groups on the effect of hyperthyroidism.Results: ⑴ Before and after treatment,the two groups of patients were afraid of the thermal score comparison: There was no statistical difference between the two groups of patients before the treatment of fear of thermal integration by the symptoms of statistical analysis,comparable.After treatment,the fear of heat in the experimental group and the control group was lower than before treatment(P < 0.05),and the group with fear of heat after treatment was significantly lower than the control group(P <0.05),indicating that the experimental group and the control group were both Can improve the symptoms of heat shock,and the experimental group was better than the control group.⑵ Comparison of hyperhidrosis scores before and after treatment in the two groups: There were no statistically significant differences in the scores of hyperhidrosis symptoms before treatment between the two groups,which were comparable.After treatment,the hyperhidrosis scores in the experimental group and the control group decreased compared with that before treatment(P < 0.05),and the score of the hyperhidrosis symptoms in the experimental group was significantly lower than that in the control group(P <0.05),indicating that the experimental group The control group could improve the symptoms of hyperhidrosis,and the effect of the experimental group was better than that of the control group.⑶Comparison of marasmus scores between the two groups before and after treatment: There was no statistically significant difference between the two groups of patients in terms of marasmus before treatment and they were comparable.After treatment,the marasmus in the experimental group and the control group was lower than before treatment(P < 0.05),and the marasmus score in the experimental group after treatment was significantly lower than the control group(P <0.05),indicating that the experimental group and the control group can be The symptoms of wasting were improved and the effect of the experimental group was better than that of the control group.⑷Comparison of food intake scores before and after treatment in the two groups: There was no statistically significant difference between the two groups of patients before the treatment and the symptoms were similar.After treatment,the food intake scores of the experimental group and the control group decreased compared with those before treatment(P < 0.05),but there was no significant difference between the two groups(P> 0.05).It was proved that the experimental group and the control group could improve the patient’s satisfaction.Symptoms of eating,and the efficacy is equivalent.⑸Comparison of irritability scores between the two groups before and after treatment in the two groups: There was no statistically significant difference between the two groups in terms of irritability before and after treatment.After the treatment,the irritability scores of the experimental group and the control group were lower than those before the treatment(P < 0.05),but there was no significant difference between the two groups(P> 0.05).It was proved that the experimental group and the control group could improve the patient’s irritability.Symptoms,and the effect is equivalent.⑹ Comparison of fatigue scores between the two groups before and after treatment in the two groups: There was no statistically significant difference in fatigue scores before treatment between the two groups,which was comparable.After treatment,the fatigue of the experimental group and the control group decreased compared with that before treatment(P > 0.05),and the fatigue value of the experimental group was significantly lower than that of the control group(P < 0.05),indicating that both the experimental group and the control group were The symptoms of fatigue were improved and the effect of the experimental group was better than that of the control group.⑺Comparing the goiter scores between the two groups before and after treatment: There was no statistically significant difference in the scores of goiters before treatment between the two groups and they were comparable.After treatment,goitre in the experimental group and control group decreased compared with that before treatment(P<0.05),but there was no statistical difference between the two groups(P > 0.05).It was proved that the experimental group and the control group can improve the goiter Situation,and the efficacy is quite.⑻Comparison of the exophthalmos scores between the two groups before and after treatment: There was no statistically significant difference in the exophthalmos scores before treatment between the two groups,which was comparable.After treatment,the exophthalmos in the experimental group and the control group decreased compared with that before the treatment(P > 0.05),and the exophthalmos score after the treatment was significantly lower in the experimental group than in the control group(P <0.05),indicating that the experimental group and the control group All can improve the symptoms of exophthalmos,and the effect of the experimental group is better than the control group.⑼The total scores of TCM syndromes in two groups of GD patients were compared: The results showed that: t-test: the difference was not statistically significant and comparable.After treatment,the scores in the experimental group and control group decreased compared with those before treatment(P < 0.05),and the scores in the experimental group after the treatment were significantly lower than those in the control group(P <0.05),indicating that both groups can effectively improve GD Symptoms of the patient and the experimental group had an advantage over the control group.⑽Comparison of the efficacy of TCM syndromes between two groups of GD patients: Rank sum test: P<0.05,indicating that both groups can effectively improve TCM symptoms of GD patients and the TCM symptoms of the experimental group improved significantly better than the control group.⑾Comparison of FT3,FT4,and TSH before and after treatment in the two groups: Before treatment,FT3,FT4,and TSH in the two groups were determined by independent sample t test,and P>0.05 was obtained.The difference was not significant,indicating that the two groups were in FT3,FT4,TSH are comparable.Compared with before treatment,after the treatment,the experimental group and the control group were analyzed by independent sample t test,all had P <0.05,there was a statistical difference,indicating that both groups of patients had significant improvement in FT3,FT4,and TSH.After treatment,the experimental group was compared with the control group,and the t-test,P>0.05,had no statistical difference,indicating that the treatment group and the control group had similar effects in improving the thyroid function indicators.Conclusions:The combination of Huangqi Jiawei Fang and methimazole in the treatment of Graves’ disease combined with traditional Chinese medicine and western medicine has a certain advantage over the use of western medicine methimazole in improving various symptoms of GD,which provides a new idea for the treatment of Graves disease in clinical practice. |
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