The Clinical Research Of Tonifying Qi,Nourishing Yin And Removing Stasis Combined With ETV For Chronic Hepatitic B Cirrhosis

Objective:The Research is to observe the clinical effect of tonifying qi,nourishing yin and removing stasis combined with ETV in the treatment of Hepatitis B cirrhosis at compensatory period.By comparing the changes of symptoms,signs and laboratory indexes before and after treatment,it discusses the significance of the Chinese medicine prescription.Methods:Patients are from infectious disease department of Jiangsu Province Traditional Chinese Medicine Hospital from June 2016 to December 2017,and 50 cases of hepatitis B cirrhosis are chosen.The patients are divided into the control group and the treatment group,25 cases in each group.The control group are only treated with ETV.The treatment group are given tonifying qi,nourishing yin and removing stasis therapy on the basis of the control group.The symptoms,signs,liver function,HBVDNA and other indicators of the two groups are recorded before treatment and 3 months and 6 months after treatment,and the adverse reactions are observed.Data statistics are analyzed by SPSS20.0 software,and that P<0.05 is statistically significant.Results:(1)Comparison of TCM symptoms and signs:after 3 months' treatment and 6 months' treatment,there is a statistically significant difference in symptoms and signs between the two groups compared with those before treatment,P<0.05.For 6 months and 3 months after treatment,the difference between two groups of symptoms and signs of the total score are statistically significant(P<0.01);the symptoms and signs of the treatment group after 6 months of treatment,compared with those of the control group,improves better,including lassitude,anorexia,dry mouth with drink less sweating,dysphoria in chestpalms-soles,hypochondriac pain like thorns,and dark complexion.The total effective rate of TCM symptom and physical sign treatment group is 88%,which is better than that of the control group(76%).(2)Comparison of liver function and HBVDNA:after 3 and 6 months of treatment,the ALT and AST are statistically significant compared with those before treatment(P<0.01).The comparison of the ALT between the two groups after 3 months' and 6 months' treatment are significant(P<0.05).The comparison of the AST between the two groups has no difference after 3 months of treatment(P>0.05),but after 6 months of treatment it is statistically significant(P<0.05)indicating that the treatment group and control group are both able to improve ALT and AST,but the treatment group is superior to the control group.After 3 months' treatment and 6 months' treatment,the HBVDNA of the two groups is statistically significant compared with that before treatment(P<0.05).There is no significant difference between the treatment group and the control group in HBVDNA after 3 months' treatment and 6 months' treatment.Conclusion:The method of tonifying qi,nourishing yin and removing Stasis combined with ETV treatment in patients with hepatitis B liver.cirrhosis can improve the clinical symptoms,including lassitude,anorexia,dry mouth with drink less sweating,dysphoria in chestpalms-soles,hypochondriac pain like thorns,and dark complexion.The treatment group could significantly improve the AST and ALT.The research is safety and worthy of further study.