Clinical Observation On Treatment Of Chronic Atrophic Gastritis With Hp Infection By Qingyou Yangwei Capsule Combined With Quadruple Combination Therapy

Objective:To observe the clinical efficacy of Qingyou Yangwei capsule combined with quadruple therapy to treat the Chronic Atrophic Gastritis with Helicobacter pylori infected.And to discuss the mechanism of Qingyou Yangwei capsule in the treatment of chronic atrophic gastritis with Helicobacter pylori infected from the perspective of TCM theory.Methods:Sixty patients who met the diagnostic criteria were enrolled in the study,and divided into treatment and control groups of 30 individuals according to a randomized method.The control group received quadruple therapy,and taking 14 consecutive days;in the treatment group,Qingyou Yangwei Capsule was added on the basis of the treatment of the control group;and taking 45 consecutive days.Two groups were observed before and after the eradication of Hp symptom scores,symptom scores and adverse reactions Hp eradication-Using statistical methods to analyze the information of the two groups patients.Results:There was no significant difference between groups in age and gender(P>0.5),and was comparable.Comparing the symptomatic effects between the two groups of patients,the experimental group was superior to the control group in the treatment of gastric cramps,mouth odor,poor appetite,pantothenic heartburn,etc(P<0.05);for the improvement of stomach pain,the two groups had the same effect(P>0.05).Comparing the clinical efficacy of the two groups,the total effective rate in the experimental group was 77%,and the control group was 50%.By statistical analysis,both methods were effective in treating chronic atrophic gastritis with Hp infected,and the experimental group was superior to the control group(P<0.05).For eradication of Hp,the eradication rate of the control group was 78%,and the experimental group was 93%,so the eradication effect of the experimental group was same with the control group(P>0.05).For the adverse symptoms,Qingyouyangwei capsule group can reduce the incidence of bitterness and diarrhea(P<0.05).Conclusion:Qingyou Yangwei capsule combined with quadruple therapy to treat chronic atrophic gastritis with Hp infected had obvious clinical efficacy.They can significantly improve the clinical symptoms,and can reduce adverse reactions,but can not increase the eradication rate of Hp.