Efficacy And Safety Of Percutaneotus Kyphoplasty (PKP) Compared With Non-surgical Care For Osteoporotic Vertebral Compression Fracture

BackgroundPercutaneous Kyphoplasty(PKP)has been increasingly used in the treatment of Osteoporotic vertebral compression fractures,but the efficacy and safety of the procedure remain unclear.We aimed to investigate if PKP has additional value compared with conservative treatment in patients with acute vertebral fractures.MethodsPatients were recruited to this open-label prospective randomised trial from the Jinan Central Hospital.Patients were aged 50 years or older,with back pain for 6 weeks or less,had vertebral compression fractures on spine radiograph,and a visual analogue scale(VAS)score of 5 or more.Patients were randomly allocated to PKP or conservative treatment.Pain relief,quality of life,function,disability were assessed for 1 year as measured by VAS score,QUALEFFO score,EQ-5D scoreand RMD score.Analysis was by intention to treat.ResultsBetween Sep 1,2015,and Sep 1 2016,122 patients who were eligible for randomization were identified.There was significant reduction(p<0.05)in pain,as measured by VAS score,started at immediate postoperative period to end of follow up period up to 1 year.No serious adverse events or complications were reported.InterpretationIn patients with acute osteoporotic vertebral compression fractures,PKP is effective and safe.Pain relief after PKP is immediate and sustained for at least 1 year.