Clinical Study Of The Curative Effect Evaluation Of Buzhongguizhi Decoction Combined With Western Medicine In The Treatment Of Chronic Obstructive Pulmonary Disease In Stable Period With Spleen And Lung Qi Deficiency Syndrome

Objective:To observation the clinical effect of chronic obstructive pulmonary disease in stable period with spleen and lung qi deficiency syndrome that were treated with Buzhongguizhi Decoction on the basis of Western medicine.And discussion the efficacy and safety of the western medicine combined with Buzhongguizhi Decoction in the treatment of chronic obstructive pulmonary disease in stable period with spleen and lung qi deficiency syndrome.All of these are provide reference and basis to the combined treatment of traditional Chinese and Western Medicine in treatment of chronic obstructive pulmonary disease in stable period.Methods:70 patients were randomly selected from the cardiopulmonary department of Yunnan Provincial Hospital of traditional Chinese Medicine who were diagnosed as chronic persistent period of chronic obstructive pulmonary disease and Feizhang of traditional Chinese Medicine（spleen and lung qi deficiency syndrome）.These subjects were randomly divided into the treatment group and the control group,with35 cases in each group.The treatment group was treated with Yunnan Province Traditional Chinese medicine Professor Wu Shengyuan experience Buzhongguizhi Decoction plus long-acting bronchodilators（budesonide/formoterol inhalation powder）;and the control group were given Liujunzi Decoction plus long-acting bronchodilators（budesonide/formoterol fumarate powder for inhalation therapy）.The time of treatment was six weeks.After finishing the treatment,TCM syndrome score,main clinical symptoms,quality of life,activity,lung function,clinical effect and acute aggravation of the two groups were compared.Results:The results showed that the scores of TCM symptoms after the treatment in the two groups were significantly decreased compared with those before treatment,and the difference was statistically significant.After six weeks treatment,the score in the treatment group（11.67±3.35）was lower than that in the control group（14.24±4.52）,and the difference was statistically significant.After six weeks treatment,the TCM syndrome scores of asthma,shortness of chest tightness,cough and phlegm were significantly lower than those before treatment,and the difference was statistically significant.At the same time,the symptom scores of asthma,shortness of chest tightness,cough and phlegm in the treatment group were lower than those in the control group,and the difference was statistically significant.After six weeks treatment,there were 4 cases were cured,18 cases were markedly effective,12cases were effective,and 1 cases were ineffective in the treatment group.There were2 cases were cured,12 cases were markedly effective,17 cases were effective,and 4cases were ineffective in the control group.According to the rank sum test,the difference of the two groups of curative effect in traditional Chinese Medicine has statistical significance.After treatment,in the treatment group there were 6 cases of grade 1 of pulmonary function,19 cases of grade 2,8 cases of grade 3,2 cases of grade 4.And in the control group there were 4 cases of grade 1,12 cases of grade 2,15 cases of grade 3,4 cases of grade 4.By rank sum test,the difference was statistically significant.In the treatment group there were 8 cases in group A of comprehensive score,19 cases in group B,6 cases in group C,2 cases in group D.And in the control group there were 5 cases in group A,14 cases in group B,15 cases in group C,4 cases in group D.By the rank sum test,the difference was statistically significant different of curative effect of western Medicine in the two groups.After treatment,the sores of CAT,mMRC and SGRQ in the two groups were significantly lower than those before treatment.The differences were statistically significant.The6MWT of the two groups were significantly higher than those before treatment,and the differences were statistically significant.Meanwhile,after treatment,the scores of CAT,m MRC and SGRQ in the treatment group were lower than those in the control group,and the difference was statistically significant.After treatment,the 6MWT in the treatment group was higher than that in the control group,and the difference was statistically significant.After treatment,the FEV₁ sores of the two groups increased,and the value of FEV₁/FVC and FEV_1/predicted value decreased,but the difference was not statistically significant.After treatment,there was no significant difference between the two groups of FEV₁,FEV₁/FVC%and FEV₁%.After 6 months of follow-up,the results showed that the acute exacerbation times in the treatment group was（0.48±0.34）,in the control group was（0.95±0.52）,the times of treatment group was significantly lower than the control group,after the rank sum test,the difference between the two groups was statistically significant.During the treatment,the safety indexes of the two groups:blood pressure,heart rate,respiration,blood routine,urine routine,chest film,electrocardiogram,no obvious abnormal.Conclusion:Professor Wu Shengyuan experience Buzhongguizhi Decoction Combined with western medicine in the treatment of chronic obstructive pulmonary disease（spleen and lung qi deficiency syndrome）in stable period was better than Liujunzi Decoction Combined with western medicine in the TCM symptom score,clinical symptoms,quality of life,activity,clinical efficacy and acute exacerbation.The combination of Buzhongguizhi Decoction and Western medicine is safe and worthy of promotion in clinical practice.