| Objective:To explore the value of general electroencephalogram(EEG)and quantitative electroencephalogram(QEEG)in thrombolysis patients with acute cerebral infarction.Methods:The patients with acute cerebral infarction were selected within 6 hours of onset time,were treated with recombinant tissue plasminogen activator(rt-PA)by intravenous thrombolytic therapy,the dose of 0.9mg/kg body weight,the first dose of 10%in 1 minutes infusion,the remaining part of the drug injected by pump to maintain 1 hours.All patients were examined with EEG before and after thrombolysis 24 hours and 1 week,and the NIHSS score was recorded at the same time.According to the international standard 10-20 system,the EEG electrodes were placed in the awake,closed eyes and quiet state for 5?10 minutes,and the baseline EEG data of 30S were obtained.Quantitative analyse and calculate the absolute power of delta,theta,alpha and beta waves in 16 brain areas,DTABR=(?+?)/(?+?)was used to represent the relatively slow wave band power value,combined with NIHSS score analysis.Results:1.Basic data analysis:a total of 32 patients were enrolled in the study,including male 18 cases and female 14 cases,left cerebral infarction 18 cases,right cerebral infarction 14 cases,thrombolysis effective patients 21 cases,and invalid 11 cases.There was no significant difference in infarction side,gender,age,thrombolysis time with thrombolytic effect(P>0.05).2.General EEG monitoring results:in 27 cases,the slow wave activity increased,with theta more frequently,and the temporal lobe and frontal lobe obvious;15 cases showed theta and delta waves increased,the ipsilateral of alpha and beta waves weaken or disappear,brain electrical activity inhibition.As the disease remission,21 patients alpha and beta wave reappear,11 patients had no improvement,then slow wave activity persists,Synek classification is II,III levels.3.Quantitative EEG monitoring results:(1)The DTABR of patients has no difference in the two groups except P4 before thrombolysis;the DTABR index decreased 24 hours after thrombolysis in effective group,but most of the invalid group the index rise,except for 02 and T5,the two groups were statistically significant,the differences of F3?F4?P4?T3 and T6 were obvious;1 week after thrombolysis in two groups the DTABR index decreased,but the effective group was lower than the invalid group,except for 02?F7?T3 and T5 regions,the two groups were statistically significant,the differences of F4?C3?P3?P4 were obvious.There was no significant difference in the NIHSS scores between the two groups before thrombolysis.The difference was obvious 24 hours and 1 weeks after thrombolysis.(2)thrombolysis effective patients with DTABR decreased,parts of brain regions DTABR index decreased significantly after 24 hours of thrombolysis,such as FP1,F3,C3,F8,T3,T4,T6,after 1 week of thrombolysis,the index continued to decline,in addition to the C4,P3,P4 and F8 brain regions,the DTABR index was significantly lower than that before thrombolysis;In the ineffective group,the DTABR index did not decrease significantly 24 hours after thrombolysis,and decreased in FP2,F4,C4,P4,02,T3,T6 brain regions 24 hours to 1 week after thrombolysis.(3)the correlation analysis showed that after thrombolysis the higher the DTABR index,the higher the NIHSS score,the positive correlation between the two index.Conclusion:1.The effect of thrombolysis in patients with acute cerebral infarction was no correlation with infarction side,gender,age and thrombolysis time.2.the frequency and wave form of general EEG can reflect the changes of brain function after thrombolysis,and the more slow wave,the more severe the brain function damage.3.the DTABR index of QEEG changes can reflect the changes of brain function after thrombolysis,the more higher the index suggesting that brain function damage is more serious,and the index can be changed as brain function change.4.There was a positive correlation between DTABR index and NIHSS score after thrombolysis. |
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