Second TURBT Versus Single TURBT For The Treatment Of Nonmuscle Invasive Bladder Cancer:a Meta-analysis

Objective:Comprehensive evaluation of secondary and single transurethral resection of non-muscular invasive bladder cancer clinical efficacy for the clinical treatment of non-muscular invasive bladder cancer to choose a more reasonable treatment.Methods:In this subject,a meta-analysis of published clinical trials was conducted on the basis of extensive search literature.Through the computer search foreign databases such as PubMed,The Cochrane Library,EMbase and domestic database,including Vipu database,China Knowledge Network,Wanfang database.Time from January 1994 to July 2016 surgical treatment of non-muscular invasive bladder cancer in the clinical control study.The two researchers independently searched the literature and screened the literature according to the established inclusion and exclusion criteria,and screened the literature according to the established criteria.Meta-analysis Results:Results A total of 488 articles were retrieved,and finally 13 clinical trials were included,A total of 1928 patients were asked for meta-analysis,of which the experimental group(second TUR)a total of 819 cases,the control group(single TURBT)1109 cases..Through data extraction and integration into the literature and Meta analysis showed that tumor recurrence after secondary electric group is lower than the single TURBT,[OR = 0.30,95% CI(0.21,0.43),P < 0.00001),the difference was statistically significant;On the rate of tumor progression,second TUR group is lower than the single TUR,[OR = 0.44,95% CI(0.24,0.80),P = 0.007).Operation time,there were no significant differences in two ways,[MD =-9.56,95% CI(-20.6,1.48),P = 0.09).Time of indwelling cathete,there is no significant difference [MD =-1.22,95% CI(-2.72,2.72),P = 0.11).Surgical complications and no obvious difference,[OR = 1.51,95% CI(0.95,2.40),P = 0.08).Conclusion:Compared with single TURBT,the tumor recurrence rate and tumor progression rate of secondary resection were lower,the difference was statistically significant.And in the operation time and indwelling catheter time,surgical complications with a single TURBT no significant difference,worthy of clinical promotion.