Clinical Study Of Hs-CRP And CTnI In Predicting The Early Recurrence Of Paroxysmal Atrial Fibrillation After Radiofrequency Ablation

Background : Atrial fibrillation(AF)is one of the most common clinical arrhythmia,the incidence rate increased with age,atrial fibrillation may induce heart failure,cause cerebral embolism,seriously affect the life quality of patients,health hazard.Atrial fibrillation resulted in a 5 fold increase in stroke risk,which indicates that atrial fibrillation is not a simple cardiovascular disease,therefore,reduce the incidence of atrial fibrillation,hospitalization rate,disability rate,mortality,is currently the most important task of atrial fibrillation treatment.Long term clinical observation,atrial fibrillation drug treatment effect is not very good,not easy to switch,especially the chronic persistent atrial fibrillation,and drug treatment of drug side effects and adverse reactions and other shortcomings.Through continuous exploration and research,at present,the status of catheter ablation in the treatment of atrial fibrillation has been continuously improved,and has been recommended as a first-line treatment of paroxysmal atrial fibrillation.However,the recurrence of atrial fibrillation after radiofrequency ablation of the event is still high,the reported recurrence rate is about 25% ~ 50%.The risk factors related to recurrence after radiofrequency ablation of atrial fibrillation including left atrial size,age,obesity,type of AF,AF duration,BNP,inflammation,P wave dispersion,with organic heart disease,anti arrhythmic drug application,to study the related factors of recurrence of atrial fibrillation after radiofrequency ablation is particularly important.Objective: To investigate the serum high-sensitivity C reactive protein(hs-CRP)and troponin I(cTnI)and early recurrence of paroxysmal atrial fibrillation after radiofrequency ablation.Methods: Selection in October 2014 to September 2016 in the first affiliated hospital of henan university of science and technology between cardiovascular internal medicine for the first time line of 3 d standard measurement system(EnSite-NAVX non-contact standard measure)under the guidance of ring electrical isolation of pulmonary veins of 60 patients with paroxysmal atrial fibrillation,according to three months whether recurrence after radiofrequency ablation(independent observation indexes: the patient’s symptoms,couplet of 12-lead electrocardiogram(ecg),and 24 hours dynamic electrocardiogram results etc)were divided into treatment success group(44 cases)and recurrence group(16 cases),respectively in the preoperative and postoperative days 1,2,3,venous blood was collected for hs-CRP and c Tn I determination of levels,more successful group and the recurrence group of preoperative and postoperative hs-CRP and cTnI changes.Results: There were significant differences in the peak levels of hs-CRP and cTnI before and after radiofrequency ablation in 60 patients with paroxysmal atrial fibrillation(P<0.05).There was no significant difference in hs-CRP and cTnI levels before radiofrequency ablation between the two groups(P>0.05).The two groups of patients with postoperative hs-CRP concentration peak,before and after the hs-CRP concentration of the maximum difference between the difference was statistically significant(P<0.05).There was no significant difference in the peak value of cTnI,the cTnI concentration before and after operation between the two groups(P>0.05).Conclusion: The change of hs-CRP concentration may be related to early recurrence of paroxysmal atrial fibrillation after radiofrequency catheter ablation,but cTnI has no significant correlation with early recurrence of paroxysmal atrial fibrillation after radiofrequency catheter ablation.