The Effects Of Rosuvastatin On Early Recurrence HsCRP And IL-6of Paroxysmal Atrial Fibrillation After Radiofrequency Catheter Ablation

Objective:In order to investigate the effect of statins on early recurrence of paroxysmal atrial fibrillation after radiofrequency ablation,observe rosuvastatin and conventional treatment for changes of Hs-CRP and IL-6after Circumferential pulmonary vein isolation in patients with paroxysmal atrial fibrillation.Methods:Selected in2011June-2013June in Department of Cardiology of Tianjin Fifth Central Hospital RFCA of patients with a total of44cases were in normal level, blood lipid. The object of study by randomly divided into control group and treatment group, the control group of22cases, male13cases, female9cases, the rosuvastatin group22cases, male12cases, female10cases. The control group (n=22), treated with amiodarone and warfarin orally, abnormal thyroid function, change the rhythm of the heart to put down the treatment, postoperative routine warfarin anticoagulation therapy for three months, to maintain the INR value to2-3. Rosuvastatin group (n=22), given amiodarone and warfarin plus rosuvastatin (10mg/later). Observation3months of recurrence, the recurrence of atrial fibrillation recurrence of AF. know through HOLER. Using ELISA to detect hs-CRP and IL-6in the immediate preoperative, postoperative2days,1months,3months, preoperative and postoperative left atrial echocardiography examination3months inside diameter. After2days,1months,3months is fixed by the physician follow-up (follow-up telephone or out-patient follow-up), data collection, to patient education, have heart palpitations symptoms immediately outpatient or inpatient department treatment, the acquisition of hs-CRP and IL-6data and HOLTER data, doppler echocardiography.Result:1. Two groups of patients with AF recurrence three months for the rosuvastatin group recurrence number3people, the recurrence rate was13.6%, control group, the number of8, the recurrence rate was36.4%, the relapse rate of the two groups had no statistical difference, the Rosuvastatin group the recurrence rate is not lower than that of the control group. Atrial tachycardia and atrial flutter in the recurrence rate is no statistically significant difference in P=0.135. There were not abnormal thyroid function in the two groups,it did not use propafenone treatment.There were1cases of abnormal liver function in the Rosuvastatin group, transaminase increased to more than3times, the recovery of liver function after stopping drug.2. Preoperative IL-6and hs-CRP levels in patients with no significant difference between two groups,2days and two groups of inflammatory factor reached the highest level after operation,1months after the operation began to decline,3months after surgery to the preoperative level. Rosuvastatin group compared to the control group, the levels of inflammatory factors after operation decreased significantly (P<0.05).3. After3months of follow-up echocardiogram two diameter of left atrium was for the statin group before and after operation there was no significant difference in left atrial diameter, the control group before and after the operation, there was no significant difference in left atrial diameter. In two groups of left atrial diameter and two groups of left atrial diameter had no significant difference before operation.