Relationship Between Primary Liver Cancer And Diabetes And Its Clinicopathologic Characteristics

Objective: To discuss the relationship between diabetes and liver cancer and their clinicopathologic characteristic,and to provide reference for the early warnings,precaution and liver cancer screening in the early stage as far as possible.Methods: This is a retrospective analysis of a prospectively collected database of 407 patients who was diagnosed PLC through the pathological diagnosis between 2008-2016 at Sichuan Provincial People’s Hospital.According to the presence or absence of HBV /HCV infection,407 patients with PLC were divided into HBV/ HCV with DM group(n=28)and HBV/HCV without DM group(n=235),DM without HBV/HCV group(n=40)and non HBV/HCV non-DM group(n=104).Data collection includes:(1)anthropometric data: gender,age,weight,height and body mass index(BMI).(2)Hepatic biochemical data:AST,ALT,γ-GGT,ALP,and TBIL.(3)Metabolic data: TC,TG,HDL and LDL,Overweight or obesity.(4)Tumor markers:AFP and SF.(5)PLC pathological characteristic: pathological diagnosis,tumor size,tumor quantity,differentiated degree and tumor metastasis conditions.Clinical characteristics were compared between patients with and without DM 。Conduct statistics and analysis of all the collected data with the statistical software SPSS17.0.Results: 1.The average age(59.83±7.91 years)and the average body weight(66.82±9.18 kg)in the HBV / HCV diabetic group were significantly higher than those in the HBV/ HCV without MD group(53.88±12.46 years)and mean body weight(60.36±10.01kg),There was significant difference(P <0.05),but there was no significant difference between sexes.The mean age(62.45 ± 7.83 years)in the DM without HBV/HCV group was significantly higher than that in the non-HBV/HCV non-DM(53.34±12.28 years),with a statistically significant difference(P <0.05).The proportion of women in DM without-HBV/HCV group(47.50%,19/40)was significantly higher than that in non-HBV/HCV non-DM group(27.88%,29/104),there was significant difference(P <0.05).There was no statistically significant difference in body weight.2.There was no significant difference in ALT,AST,γ-GGT,ALP and TBIL between HBV/HCV with DM group and HBV/HCV non-DM group(P >0.05).The levels of ALT and AST in non-HBV/HCV diabetic group were significantly lower than those in non-HBV/HCV non-DM group(P <0.05),and there was no significant difference in residual γ-GGT,ALP and TBIL(P >0.05).3.The level of TG(1.61 ± 0.38 mmol / L),overweight or obesity(50%,14/28)in HBV /HCV with DM group was significantly higher than that in HBV / HCV non-DM group(1.23 ± 0.54 mmol / L)The proportion of overweight or obesity(23.48%,54/230)was statistically significant(P <0.05).There was no significant difference in TC,HDL and LDL.The level of TG(1.89 ± 0.63 mmol / L),the proportion of overweight or obesity(60%,24/40)in non-HBV / HCV DM group was significantly higher than that in non-HBV/ HCV non-DM group(1.29 ± 0.87 mmol / L),Overweight or obesity(30%,30/100),there was a significant difference(P <0.05).There was no significant difference in TC,HDL and LDL.4.There was no significant difference in SF and AFP between HBV/HCV with DM group and HBV/HCV non-DM group(P >0.05).There was no significant difference in SF and AFP between non-HBV/ HCV DM group and non-HBV/HCV non-DM group(P > 0.05).5.The percentage of tumor metastasis in the HBV / HCV diabetic group was significantly higher than that in the HBV / HCV non-diabetic group(P <0.05),which was significantly higher than that in the non-HBV / HCV diabetic group(P <0.05)There were no significant differences in tumor pathological type,tumor differentiation,tumor number and tumor size.There were no statistically significant differences in tumor pathological type,tumor differentiation,tumor number,tumor size and tumor metastasis rate between non-HBV /HCV diabetic group and non-HBV / HCV non-diabetic group.Conclusion: 1.In patients with primary liver cancer,comorbidity DM is older than non-DM patients.Non-HBV/HCV infection in women with DM than non-HBV/HCV infection in women with non-diabetic prone to liver cancer.2.Overweight or obesity in patients with liver cancer complicated with diabetes mellitus was significantly higher than that in non diabetic patients,It is speculated that metabolic factors may play an important role in the occurrence and development of liver cancer.3.HBV/HCV infection with diabetes may be more likely to promote tumor metastasis in patients with liver cancer.