Association Between Oxcarbazepine-induced Cutaneous Adverse Drug Reactions And HLA-B~*15:02 Alleles In Asians Population:a Meta-analysis

Objective To explore the association between oxcarbazepine-induced cutaneous adverse drug reactions and HLA-B*15:02 alleles in Asians population.Methods We set the search strategy according to the PICOS.The search strategy combined the key words and mesh word.We searched Pub Med,EMBASE,the Cochrane Library,CNKI,Wangfang database,VIP database(Dec.2016)and identified trials with the inclusive criteria.Risk of bias was assessed using the criteria of the Cochrane back review group.Than the character and the data of all included studies was extracted,the meta-analysis of included case-control studies was performed to assess the association between oxcarbazepine-induced cutaneous adverse drug reactions and HLA-B*15:02 alleles in Asians population.Results 7 case-control studies with 1761 patients were included.There was no statistically significant difference in the frequency of the HLA-B*15:02 allele between the OXC-induced MPE and the OXC-tolerant control groups(OR=1.11,95%CI:0.43,2.83,P=0.83).As well as between the OXC-induced MPE group and the normal control group.(OR=1.72,95%CI:0.75,3.94,P=0.20).Conclusion In conclusion,we found no significant association between OXC-induced MPE and the HLA-B*15:02 allele in Asians population.The association between OXC-induced SJS/TEN and the HLA-B*15:02 allele need to be further assessed by more case-control studies...