The Discussion Of Thyroid Hormone Reference Range In Trimester-specific During Woman Pregnancy In The Area Of Lanzhou

Objective:To investigate trimester-specific reference range of thyroid hormone during pregnant women in LanZhou,the Province of GanSu.To establish and analyze the trimester-specific reference range of thyroid hormone during pregnant women in Lanzhou area of Gansu province.Also,during pregnancy,to conduct the diagnosis and treatment of thyroid diseases,to avoid the misdiagnosis and misdiagnosis of thyroid disease.Thus,to improve the quality of maternal and child health,prenatal care for escort.Methods: According to the National Academy of Clinical Biochemisty(NACB)recommended research methods,thyroid hormone levels during pregnancy medical reference range of 95% confidence interval,choosing the women for who from October 2015 to June 2016 in the Second Hospital of Lanzhou University obstetrics and gynecology department,checking-in singleton pregnancies healthy pregnant women 562 cases,of which during early pregnancy(T1)238 cases and second trimester(T2)192 cases,and third trimester(T3)132 cases,as the group of experimental.In the addiction,52 cases of selected non-pregnant(T0)women of childbearing age as a healthy control group.A volume of 5 ml of venous blood was taken from each patient.All the fasting venous blood was taken from 8:00 to 12:00 in the morning,and placed in the vacuum yellow cap to promote blood collection.The rats were treated with 3500 r / min LC-4012 low-speed ce ntrifuge for 2h.Centrifuge,centrifuge for 15 minutes,then take into the Siemens ADVIA Centaur XP fully automated chemiluminescence immunometer detector to detect chemiluminescence thyroid hormone,including thyroid-stimulating hormone(TSH)and free thyroxine(FT4)as well as three free triiodothyronine(FT3).and the results were statistically analysis,thyroid hormone during pregnancy in the area of medical reference ranges.Results: TSH reference range during pregnancy in the first trimester,second trimester,third trimester of pregnancy were respectively 0.05 ~ 5.58 m IU / L,0.26 ~ 4.80 m IU / L,0.21 ~ 5.11 m IU / L;FT4 reference range in pregnant early,middle and late,respectively 10.73 ~ 19.15 pmol / L,10.26 ~ 18.06 pmol / L,9.94 ~ 16.35 pmol / L.TSH lowest in early pregnancy,FT4 highest pregnancy reference ranges of each are different,there are differences in pregnancy and non-pregnancy reference ranges,there are also differences in the respective periods.P<0.05.Conclusion: it is very important and necessary to build the reference ranges of thyroid hormones during pregnancy,Lanzhou,Gansu Province...