Correlation Analysis Of Prevalence,risk Factors And Clinical Changes In Acute Perforating Artery Cerebral Infarction With Cerebral Microbleeds

This study mainly to explore the prevalence,risk factors and clinical changes in different parts of acute perforating artery cerebral infarction with cerebral microbleeds.This study adopted collected acute perforating artery cerebral infarction with cerebral microbleeds in Central Hospital of Handan were selected.Combination of cranial DWI and SWI sequence inspection results,screened the basal ganglia thalamus and brainstem areas of acute cerebral artery perforator combined with CMBs as research objects.Clinical information,risk factors and neurological function score were recorded.The subjects were divided into two groups according to the location of the new infarction: basal ganglia thalamus infarction and brainstem infarction.According to the MARS forms,the number of CMBs of relevant parts of each group of responsible lesions CMBs were recorded.Statistical analysis of different parts of acute perforating artery cerebral infarction microbleeds prevalence,risk factors and clinical changes.This study included 214 consecutive patients with acute perforating artery cerebral infarction were inrolled in this study,6 cases of failing to complete follow-up,10 cases of non basal ganglia thalamus and brainstem areas of acute perforating artery in patients with cerebral infarction.A total of 198 cases acute perforating artery cerebral infarction entered statistical analysis,of which with basal ganglia thalamus or brainstem areas of acute perforating artery cerebral infarction with CMBs(positive group)103 cases and without CMBs(negative group)95 cases.Positive group of hypertension incidence rate of 80.6%,significantly higher than the negative group 63.2%(χ2 =4.51,P=0.03).There were no statistically significant differences in other risk factors.Brain basal ganglia thalamus infarction patients with CMBs was 67 cases and brainstem infarction with CMBs 36 cases.Brain basal ganglia thalamus infarction patients with CMBs hypertension incidence rate was 86.6%,higher than that brainstem infarction with CMBs hypertension incidence rate 69.4%(χ2 =4.39,P=0.04).The number of CMBs was 280(4.2±4.8)in ipsilateral supratentorial in Basal ganglia thalamus infarction group,higher than the number of CMBs in supratentorial infarction in brainstem infarction group 23(0.64±3.2)(t=5.18,P=0.00).The number of CMBs was 174(4.8±3.2)in brainstem in brainstem infarction group,higher than the number of CMBs in brainstem in basal ganglia thalamus infarction group 62(0.93±1.2),(t=8.8,P=0.00).Correlation analysis of neurological function score and CMBs indicated: There was no significant correlation between the NIHSS score in patients on admission with cerebral infarction with the number of CMBs associated with responsible lesions(r=0.091,P=0.363);there was significant correlation between the improvement of neurologic deficit in 3 months later with the number of CMBs associated with responsible lesions(r=0.381,P=0.001).The high prevalence of CMBs in patients with acute cerebral artery perforator.High blood pressure plays an important role in the formation of CMBs with basal ganglia thalamus infarction.The NIHSS score at admission was not related with the number of CMBs associated with responsible lesions,but the improvement of neurologic deficit in 3 months later was related with the number of CMBs associated with responsible lesions,the more the number of CMBs in the infarct area,the worse the recovery of neural function.Magnetic susceptibility weighted imaging scans in patients with acute perforating artery cerebral infarction has important significance for the primary prevention and two clinical evaluation of patients with acute period.