Nalbuphine For Clinical Observation Of Treatment Of Pediatric Postoperative Analgesia

Objective:To compare the clinical efficacy of nalbuphine versus sufentanil in postoperative analgesia in children and to observe the safety and effectiveness of nalbuphine for pediatric postoperative analgesia by setting up two different dose nalbuphine groups for clinical efficacy comparison, in order to provide a dose reference for clinical pediatric application of nalbuphine.Methods:120 patients underwent tonsillectomy (low-temperature plasma radiofrequency ablation) were selected and randomly divided into four groups (n = 30 in each group).All the four groups were given PCA 10 min before the end of surgery. Group A:nalbuphine 1.0 mg/kg + ketorolac 0.5 mg/kg + dexamethasone 0.15 mg/kg; group B:nalbuphine 1.5 mg/kg + ketorolac 0.5 mg/kg + dexamethasone 0.15 mg/kg; group C:sufentanil 1 ug/kg + ketorolac 0.5 mg/kg + dexamethasone 0.15 mg/kg; and group D:blank group (no use of postoperative analgesic pump).Results:Pairwise comparison between groups A, B and C found no significant differences in FLACC score at 2 h, 12 h, 24 h and 48 h postoperatively (all P > 0.05).FLACC score of group A differed significantly from groups B and C at 4 h postoperatively (all P < 0.05). FLACC scores of groups A and C differed significantly from group B at 8 h postoperatively (all P < 0.05), while did not differ significantly between groups A and C (all P > 0.05). As for the postoperative sedation score, no significant differences were found between groups A, B and C at 2 h postoperatively(P> 0.05). Sedation scores of groups A and C differed significantly from group B at 4h and 8 h postoperatively (all P < 0.05), while did not differ significantly between groups A and C (all P > 0.05). Groups A, B and C exhibited hospital stay, FLACC score and postoperative sedation score all significantly different from group D (all P <0.05).Conclusion:1 mg/kg nalbuphine has a good mild-to-moderate postoperative intravenous analgesic effect and a satisfactory sedative effect in children, which can effectively reduce postoperative irritability and has small adverse reactions, thus is safe for postoperative analgesia in children.