Destruction Of Nasal Mucosal Barrier Function Of Chronic Rhinosinusitis And Allergic Rhinitis And Changes Of Tight Junction Proteins Expression

Rhinitis is defined as inflammation of the nasal mucosa and affects up to 40% of thepopulation.Among all causes of mucosal inflammation,allergic rhinitis(AR)is the most common,affecting 1 in 6 individuals.Symptoms of AR interfere with all facets of daily life and are associated with reduced quality of sleep and work performance.Previously thought of as a disease restricted to the nasal passages,AR is now viewed as a manifestation of systemic airway disease and is often comorbid in patients with asthma.The airway epithelium of allergic asthmatic patients has been shown to have a number of defects,including decreased expression of intercellular junction proteins,increased susceptibility to injury,dysregulated repair,and increased proliferation.Chronic rhinosinusitis(CRS)is a kind of sinonasal mucosa inflammatory disease.It has ahigh clinical incidence rate.It affects approximately 15% of the general population and the inflammation affects patients ’ life quality and work efficiency.Its pathogenesis is not clear.At present,a number of studies have sho wn that chronic inflammatory diseases,such as asthma,skin diseases and Crohn,are a ssociated with changes in the expression of tight junction proteins in mucosal epitheli al cells and destruction of epithelial barrier function.At present,some studies suggest that the nasal mucosa of CRS patients is also involved in destruction of epithelial barr ier function and changes in the expression of tight junction proteins.This article is ai med to review research progress of destruction of CRS nasal mucosa epithelial barrier function and changes in the expression of CRS nasal mucosa tight junction proteins,and tries to further analyze the pathogenesis of CRS from the level of nasal mucosa e pithelial barrier function.