The Influence Of Using Statin After Cardiac Transplant:a Meta-Analysis

Background Although a lot of studies found the positive impacts of statins in post-heart transplantion patients,but these were relatively small and low-powered researches.Thus we performed a meta-analysis of published researches to evaluate the influence of statins in post-heart transplantion patients,especifcally evaluating the role on hemodynamically signifcant or fatal graft rejection,terminal cancer,coronary vasculopathy,and overall survival.Methods and Results We searched the PubMed,Web of Science databases,and Cochran CENTRAL.We use the terms "cardiac transplant"or "heart transplant," and "statin" for the search.And we use the random-effects model with Mantel-Haenszel method to pool the data.We identifed 10 studies,including 4 randomized controlled trials and 6 nonrandomized studies,we compared the outcomes in cardiac transplantion patients who were undergoing statin therapy to these statin-naive recipients.A pooled analysis of 9 studies which reporting mortality found that the applying of statins was associated with remarkable decrease in all-cause mortality(odds ratio[OR],0.26;95%confdence interval,[95%CI]0.20-0.35;P<0.0001).Statins also reduced the odds of hemodynamically signifcant or fatal rejection(odds ratio[OR],0.37;95%confdence interval[95%CI],0.21-0.65;P=0.0005),terminal cancer(odds ratio[OR],0.30;95%confdence interval[95%CI],0.15-0.63;P=0.002),and incidence of coronary vasculopathy(odds ratio[OR],0.33;95%confdence interval[95%CI],0.16-0.68;P=0.003).Conclusions The proof from a pooled analysis indicates that statins raise survival in cardiac transplantion patients.Statins may have the prevention of fatal rejections,reduce terminal cancer risk,and decrease the incidence of coronary vasculopathy.But it is still needed to find additional prospective researches to further look into and explain this association.