Reversal Of Progress In Study On The Mechanism Of Drug Resistance Of Ovarian Cancer Cells

In recent years,the mortality rate of ovarian cancer is seen to be very high among the mortality rates of malignant tumors seen in Gynecology.Currently,both at home and abroad the use of surgical treatment joined with chemical drug treatment as an integrated treatment method is very common.Commonly used chemotherapy regiments include parking glycosides + Shun Platinum + blogs mold pigment(BEP programme),parking glycosides + Shun Platinum(EP programme),and Shun Platinum + Changchun alkali + different ring p n Amine(VIP programme)visible Shun Platinum.These regiments are suitable for use both before and after surgical treatment of ovarian cancer.These chemotherapy drugs effectively play a vital role in the inhibition of malignant ovarian cell development.Results after use of these drugs are rather conspicuous.However,the bulk of the data confirmed that 60%-70% of patients with ovarian cancer show resistance to cisplatin,resulting in poor prognosis.The 5-year survival rate had significantly dropped when using chemotherapy drugs,thus reversing ovarian cancer cell development(SKOV3/DDP)has beco me the focus of recent studies on drug resistance.How ovarian cancer cells which show resistance to Platinum and their influence is the pivotal question of ovarian cancer treatment.Therefore,ovarian cancercells resi stance to Platinum mechanism and how to reverse this is a problem to be solved.Common mechanisms of drug resistance in ovarian cancer includes cell apoptosis inh ibition,DNA damage and repair capacity,Platinum body detoxification process of no nspecific enhancements and ovarian cancer drug pumps out more,but there is no spec ific theory of understanding to clarify the mechanisms on how ovarian cancer cells develop resistance.