Series Studys On The Reversal Of Multidrug Resistance In Drug-Resistant Ovarian Cancer Cell Lines By Small Interference RNA

Section â… :THE ESTABLISHMENT OF HUMAN OVARIANCARCINOMA DRUG RESISTANT IN VITRO MODELS ANDTHE CORRELATED STUDYObjective: multidrug resistance (MDR) is a phenomenon that cancer cells develop a cross-resistant phenotype against several unrelated drugs that differ widely with respect to molecular structure and target specificity, which is a serious obstacle to chemotherapy in ovarian cancers. Overexpression of MDR1, a member of the ABC (ATP-binding cassette) transporters, has been directly implicated in resistance to a broad spectrum of chemotherapeutic reagents. Consequently, it is necessary to develop less toxic and more efficient strategies to overcome MDR. However, there are little in vitro models for us to use at present. In this study, two ovarian carcinoma drug-resistant cell sublines was established to explore the developmental...