Expression Of YKL-40, RBP-4 In Peripheral Blood Of The Patients With Psoriasis Vulgaris And The Impact Of NB-UVB Therapy

Objective:(1)To evaluate the serum level of YKL-40 and RBP-4 in the patients with psoriasis vulgaris , to investigate the pathogenesis of the psoriasis vulgaris and the correlation of serum YKL-40. RBP-4 with it.(2)To evaluate the serum level of YKL-40 and RBP-4 after NB-UVB therapy,research the mechanism of phototherapy in psoriasis vulgaris and its influence on cytokine and adipokine.Method:(1)Sera were obtained from the venous blood samples from 28 patients with psoriasis vulgaris and 24 normal human controls. Enzyme-linked imunosorbent assay(ELISA) was used to examine the levels of YKL-40 and RBP-4 in the sera.(2) Sera were obtained from the venous blood samples from 25 patients with basal therapy and 20 patients with basal therapy combined phototherapy.Enzyme-linked imunosorbent assay (ELISA) was used to examine the levels of YKL-40 and RBP-4 in the sera.Results:(1)The levels of serum YKL-40 and RBP-4 were significant higher in the patients of psoriasis vulgaris than in the normal controls (128.42±24.32 ng/mL,31.95±8.28 ng/mL , P<0.05 ) ,( 15.31±3.34 μg/mL , 9.53±2.14 μg/mL ,P<0.05 ,respectively).(2) The levels of serum YKL-40 of patients with basal therapy combined phototherapy were lower than patients with basal therapy (96.05±17.93,109.89±14.57 ng/mL, P<0.05); The levels of serum RBP-4 between basal therapy、basal therapy combined phototherapy had no significant difference( 11.36±4.22,10.97±3.26μg/mL, P>0.05)Conclusion:The higher levels of serum YKL-40 and RBP-4 in the patients of psoriasis vulgaris suggesting that they may be involved in the pathogensis of psoriasis vulgaris;The phototherapy has positive influence on the YKL-40,but no effect on the RBP-4.