| Objective1 To preliminarily discuss the distribution regularity of TCM Syndrome of the patients with asthma-COPD overlap syndrome(ACOS).2 To observate the changes of TCM symptom integral,lung function,serum inflammatory factors IL-2、IL-13,total serum IgE,FeNO of ACOS patients with the syndrome of kidney deficiency phlegm turbid by treating with Yanghe Pingchuan Granules.Methods1 A TCM syndromatic questionnaire was made after reviewing the related information,using the method clinical investigation questionnaires,collecting and recording relevant information and analysis of ACOS syndrome distribution of TCM.2 Select on February 2015-December 2016 in the first affiliated hospital of anhui medical university can be diagnosed ACOS patients with syndrome of kidney deficiency phlegm turbid,a total of 40 patients,according to random numeration table,randomly assigned to control group and treatment group,20 cases in control group,20 cases in treatment group.Control group are using western medicine treatment,the treatment group is on the basis of the control group used to Yanghe Pingchuan Granules,the course of 14 days.After a period of treatment to observe two groups of patients before and after treatment of TCM symptom integral,long function(FEV1,FVC,FEV1/FVC)and the change of the serum inflammatory factors(IL-2,IL-13),total serum IgE,FeNO.Results1(1)In the 81 ACOS patients,there are 65 males and 16 females respective accounting for 80.25% and 19.75%.Smokers who smoked more than 30 years accounted for67.79% of the total.Smokers who smoked more than 20 cigarettes per day accountedfor 88.13%.The course of disease is mainly concentrated in 11-20 years.(2)In the distribution of symptoms of traditional Chinese medicine,cough,sputum,shortness of breath and chest tightness are most common.Light red tongue,slight white tongue fur and slippery pulse are the main in the tongue and pulse distribution.(3)In TCM syndrome distribution with syndrome of phlegm-dampness accumulated in the lung+syndrome of yang deficiency of lung and kidney 14 cases(17.28%),syndrome of phlegm-dampness accumulated in the lung+kidney yang deficiency syndrome 9 cases(11.11%),phlegm and blood stasis syndrome+syndrome of yang deficiency of lung and kidney 9 cases(11.11%),syndrome of phlegm and heat accumulated in lung+syndrome of lung and kidney qi and yin deficiency 8 cases(9.88%),phlegm and blood stasis syndrome+syndrome of lung and kidney qi and yin deficiency 7 cases(8.64%),syndrome of phlegm and heat accumulated in lung 7 cases(8.64%),syndrome of phlegm-dampness accumulated in the lung 6 cases(7.41%),syndrome of phlegm-dampness accumulated in the lung+symptom of lung and spleen qi weaken 6 cases(7.41%),phlegm and blood stasis syndrome+syndrome of lung and kidney qi deficiency 5 cases(6.17%),syndrome of phlegm and heat accumulated in lung+syndrome of qi deficiency of lung and kidney 3 cases(3.70%),syndrome of phlegm-dampness accumulated in the lung+syndrome of lung and kidney qi and yin deficiency 2 cases(2.47%),syndrome of phlegm-dampness accumulated in the lung+symptom of lung and spleen qi weaken 2 cases(2.47%),phlegm and blood stasis syndrome 2 cases(2.47%),phlegm and blood stasis syndrome+symptom of lung and spleen qi weaken 2 cases(2.47%).2(1)Two groups of patients before and after treatment in TCM symptom score comparison: two groups of patients before treatment in TCM symptom score comparison were no statistical significance(P>0.05);the TCM symptom score of the two groups,after treatment,was decreased significantly than before treatment(P<0.01);the treatment group of TCM syndrome score,after treatment,was statistical significance(P<0.05),compared with the control group after treatment.The curativeeffect of TCM syndrome with the treatment group(95%)was augmenter,compared with the control group(65%),and the result was significant(P<0.05).(2)Two groups of patients before and after treatment in lung function comparison:two groups of patients before treatment in lung function(FEV1,FVC,FEV1/FVC)comparison were no statistical significance(P>0.05);the lung function(FEV1,FVC,FEV1/FVC)of the two groups,after treatment,was increased significantly than before treatment(P<0.05 or P<0.01);the treatment group of lung function(FEV1,FVC,FEV1/FVC),after treatment,was statistical significance(P<0.05 or P<0.01),compared with the control group after treatment.(3)Two groups of patients before and after treatment in serum IL-2 comparison: two groups of patients before treatment in serum IL-2 comparison were no statistical significance(P>0.05);the serum IL-2 of the two groups,after treatment,was increased significantly than before treatment(P<0.01);the treatment group of serum IL-2,after treatment,was statistical significance(P<0.01),compared with the control group after treatment.(4)Two groups of patients before and after treatment in serum IL-13 comparison:two groups of patients before treatment in serum IL-13 comparison were no statistical significance(P>0.05);the serum IL-13 of the two groups,after treatment,was decreased significantly than before treatment(P<0.01);the treatment group of serum IL-13,after treatment,was statistical significance(P<0.01),compared with the control group after treatment.(5)Two groups of patients before and after treatment in total serum IgE comparison:two groups of patients before treatment in total serum IgE comparison were no statistical significance(P>0.05);the total serum IgE of the two groups,after treatment,was decreased significantly than before treatment(P<0.01);the treatment group of total serum IgE,after treatment,was statistical significance(P<0.05),compared with the control group after treatment.(6)Two groups of patients before and after treatment in FeNO comparison: twogroups of patients before treatment in FeNO comparison were no statistical significance(P>0.05);the Fe NO of the two groups,after treatment,was decreased significantly than before treatment(P<0.01);the treatment group of FeNO,after treatment,was statistical significance(P<0.05),compared with the control group after treatment.Conclusion1 With investigative 81 cases of ACOS patients,syndrome of phlegm-dampness accumulated in the lung and syndrome of yang deficiency of lung and kidney were the common and main syndrome.2 Yanghe Pingchuan granules can decrease ACOS patients in syndrome of kidney deficiency phlegm turbid with TCM symptom score,delaying the decline of lung function.3 Yanghe Pingchuan granules can decrease ACOS patients in syndrome of kidney deficiency phlegm turbid with serum inflammatory factor IL-13,total serum IgE,FeNO and increase the level of IL-2. |
PDF Full Text Request