The Relationship Research Between Blood Lipid And Ischemic Stroke In Patients With Nonvalvular Atrial Fibrillation

Objective:studying the relevance of the blood lipid with ischemic stroke in patients with nonvalvular atrial fibrillation(AF).Methods: patients with nonvalvular atrial fibrillation are 2470 cases,recording patients’ clinical data and laboratory examination in the hospital.In which,Grouped by the history with and without ischemic stroke,1910 cases don’t have ischemic stroke history,560 cases have ischemic stroke history;Grouped by CHA2DS2-VASc score,CHA2DS2-VASc score < 2 points are 566 cases(low-middle risk),score≥2 points are 1904 cases(high risk group).The differences of all the clinical indexes of two groups were respectively compared,and further studying the relevance of the blood lipid with ischemic stroke in patients with nonvalvular atrial fibrillation.Results:There was significant difference in the proportion of Han,the ratio of gender,age,hemoglobin,hematocrit,ALT,serum uric acid,HDL-C and LDL-C between the patients with ischemic stroke history and without(all P < 0.05).Similarly,there were significant differences in the proportion of Han,the ratio of gender,age,white blood cell count,hemoglobin,hematocrit,platelet count,ALT,albumin,TG and LDL-C between subjects in the low-middle risk group and those in the high risk group(all P < 0.05).A logistical regression analysis showed that LDL-C was an independent risk factor for both the ischemic stroke history(OR 2.089,95% CI 1.860-2.347,P < 0.05),and future ischemic stroke risk(OR 1.270,95% CI 1.079-1.494,P<0.05)in patients with nonvalvular AF.Conclusion:LDL-C is associated with ischemic stroke in patients with nonvalvular AF,and it is also an independent risk factor for future ischemic stroke in these patients.