A Study On The Variation Of Salivary Cortisol During Solar Terms Near Winter Solstice And Summer Solstice Among Uyghur Obesity Hypertension Patients

Objective: To discuss the difference of seasonal variation in salivary cortisol between Uyghur obese hypertension patients and health subjects,and to describe its numerical range and secretion curve during solar terms near winter solstice and summer solstice.Method:A total of 80 cases(obesity hypertension,obesity-non hypertension,non-obesity hypertension and health subject)from Xinjiang Uygur autonomous region hospital of TCM hospitalization or medical center(2015.11-2016.01 near winter solstice;2016.05-2016.07 near summer solstice)were recruited in this self-control study.Salivary cortisols from subjects were collected for 10 times one day.The secretion curve was displayed by awakening cortisol,cortisol awakening response,late descending branch and area under the curve.Body mass index,waist circumference,blood pressure and other general information were measured or collected.Combining with the theory of correspondence between man and universe,the levels of salivary cortisol in obese groups and non-obese groups during solar terms(near winter solstice and summer solstice)were compared in order to describe the basic secretion pattern.Result:The salivary cortisol level(60min after awake)summer solstice was higher than winter solstice(P<0.05).The salivary cortisol level(60min after awake)and the late descending slope were higher in obese groups than non-obese groups(P<0.05).Other detection points,splopes,areas(P>0.05).Throughout the cortisol secretion median graph,summer solstice trends to be higher than winter solstice,obesity than non-obese group has a higher trend.The whole-day secretion curve obesity hypertension group and obesity non-hypertension group had higher median curve than non-obese hypertension group and health subjects;Except for health subjects,all the other three groups had peak values(30m after awake).The tendency of cortisol level decreasing with the time was observed in all groups.Cortisol value and rhythm were synchronized with the season trend,which was elevated in summer and reduced in winter.Its pattern was in accordance with theories of waxing and waning as well as mutual transformation of yin-yang,which possibly manifested the possible mechanism of kidney yang-energy reservation in winter.Conclusion: Cortisol level and the whole-day secretion curve had seasonal variations trend during winter and summer season.To be the cortisol,obesity group has a higher trend than non-obese.This study provided partial basic data for further investigation on the secretion pattern in Uyghur obesity hypertension patients and accorded with the theory of correspondence between man and universe.