Study On The Correlation Between Serum Gonadotrophin Surge Attenuating Factor(GnSAF) Level And Ovarian Reserve

Objective:By gauging the density of the gonadotrophin surge attenuating factor(Gn SAF)and AMH and sex hormones in serum,recording their age and so on,analyzing the correlation between the indicators,to explore the clinical value of ovarian reserve.Methods:Two hundred and forty four women with different ovarian reserve were recruited in the study and assigned into three groups as follow:60with normal ovarian reserve;73 with decreased ovarian reserve;111with high ovarian reserve;electrochemiluminescence was used to gauging the density of sex hormones,including follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol;ELISA was used to gauging serum level of Gn SAF and AMH;recording their age and AFC;comparing their difference between groups and analysing their correlation.Results :There was statistically significant difference in AMH、age、FSH、LH and E2 between the three groups(P<0.01);there was no correlation between Gn SAF and the other indexs;there was a negative correlation between AMH and FSH、age,while there was a postive correlation between AMH and LH、E2、AFC.There was no statistically significant difference in Gn SAF between the three groups(P>0.05);the serum level of Gn SAF in high ovarian reseve group was higher than that in decreased group and normal group,but there was no statistically significant difference.Conclusion:(1)Gn SAF level have no correlation with the ovarian reserve.It needs more large samples and excluding more influencing factors to study further.(2)AMH and AFC have a significantly correlation with age and FSH and the other indicators of ovarian reserve.(3)In the prediction of ovarian reserve,combining with AMH and AFC and other indicators have a more effective.