Correlation Between Myeloperoxidase And Severity Of Coronary Artery Disease In Patients With Coronary Heart Disease Complicated With Type2 Diabetes Mellitus

Objective:Plasma myeloperoxidase(MPO)concentration of patients with coronary heart disease(CHD)combined with Type 2 diabetes mellitus(T2DM)was detected.To investigate the correlation between MPO level and severity of coronary artery disease in patients with coronary heart disease complicated with type 2 diabetes mellitus.Methods:A total of 298 patients with chest pain or chest tightness who were admitted to Fenyang Hospital of Shanxi Province from January 2020 to October 2021 and underwent coronary angiography(CAG)for the first time were selected.The general clinical data of the selected subjects were collected and divided into four groups according to their diseases: A,B,C and D,of which 70 cases in group A(normal control group,CHD and T2 DM group),25 cases in group B(T2DM group without CHD),98 cases in group C(CHD group without T2DM)and 105 cases in group D(CHD group with T2DM).Plasma MPO levels were detected in all subjects and Gensini scores were performed to determine the degree of coronary artery lesions according to CAG results.Comparison between multiple groups A,B,C and D was performed by one-way ANOVA,and pairwise comparison between groups was performed by LSD test on the basis of statistically significant differences among each group.Logistic regression was used for multivariate analysis of group D.Spearman correlation analysis(non-binormal distribution)and Pearson linear correlation analysis(binormal distribution)were used to determine the relationship between Gensini score and MPO level.P<0.05 considered that the difference was statistically significant.Results:1.There was no statistical significance in age,gender,history of hypertension,smoking history,drinking history,TC and TG among the four groups(P>0.05).Fasting blood glucose,Hb A1 c,HDL,LDL,MPO and Gensini scores were statistically significant(P<0.05).On this basis,pairwise comparison was conducted among the four groups,and the results showed that fasting blood glucose,MPO and Gensini scores of group D(CHD with type 2 diabetes group)were statistically significant compared with those of the other three groups(P<0.05).2.MPO was a risk factor for CHD combined with type 2 diabetes(group D)in multivariate Logistic regression analysis of the indicators with statistical significance in the above univariate analysis(OR=1.030,P<0.05).3.The normal test showed that group B was in line with the double normal distribution,and Pearson correlation analysis was adopted.The other groups were not in line with the double normal distribution,and Spearman correlation analysis was adopted.The results showed that MPO was positively correlated with Gensini score in all subjects(r=0.674,P<0.05).The correlation analysis between MPO and Gensini score in four groups showed that group A(r=0.363,P<0.05),group B(r=0.609,P<0.05),group C(r=0.672,P<0.05),group D(r=0.906,P<0.05)MPO was positively correlated with Gensini score in the four groups,and the correlation coefficient was greater in group D(coronary heart disease combined with type 2 diabetes).Conclusion:MPO is a risk factor for coronary heart disease combined with type 2 diabetes,and MPO level has a certain predictive value for the degree of coronary artery disease in patients with coronary heart disease combined with type 2 diabetes.