Analysis Of Related Factors Of Hyponatremia After Transsphenoidal Pituitary Adenoma Resection

Objective:To analyse the related factors of hyponatremia after transsphenoidal surgery for pituitary adenoma,and to provide the theoretical basis for the prevention and treatment of postoperative complications。Methods:The patients with pituitary adenoma treated by transanal sinus pituitary adenoma resection were selected as the study subjects.Twenty patients with hyponatremia were selected as the case group,28 patients without hyponatremia were selected as the control group by randomized digital table method.To analyse the relationship between gender,age,tumor type,tumor growth pattern,duration of disease and hyponatremia after transsphenoidal surgery for pituitary adenoma.Results:Various factors were associated with postoperative hyponatremia in univariate analysis,there was no statistically significant difference between course of disease(p=0.602),sex(p=0.353),tumor pathologic type(p=0.979)and postoperative hyponatremia.Age(p=0.019),tumor growth pattern(p=0.027)and postoperative hyponatremia occurred statistically significant.In multivariate regression analysis,age(p=0.033)and tumor growth pattern(p=0.045)were included in the regression equation at the inspection level of 0.05,suggesting that age and tumor growth were significantly associated with hyponatremia after pituitary adenomas.The risk of hyponatremia in patients from age group over 50 years old was 4.082 times higher than that in the under 50 year old age group.The risk of developing hyponatremia in patients’with tumor development on the saddle was that the tumor was confined to the saddle growth group of 3.88 times.Sex,tumor type,course of disease and postoperative hyponatremia had no significant correlation.Conclusion:1.Age and tumor growth pattern were risk factors for hyponatremia after transsphenoidal pituitary adenoma resection.2.There was no significant correlation between sex,tumor pathology,course of disease and postoperative hyponatremia.