The Study Of The Chronic Nasal Sinusitis With Nasal Polyps Classified By The Tissue Eosinophils

Objective To study the cutoff point of chronic nasal sinusitis with nasal polyps(CRSw NP)classified by the tissue eosinophils(Eos).Methods 140 CRSw NP patients in our hospital were enrolled in this study.The data of their clinical feature were collectted before surgery.Mucosal specimens were assessed for the presence of tissue eosinophil cells.Follow up and record the data at 3 months and6 months after surgery.These methods included the nonparametric distribution for evidence of an eosinophilia threshold effect and the minimum p-value approach.Six cut-points were compared including:≤2 eosinophil/HPF,≤6 eosinophils/HPF,≤17eosinophils/HPF,≤ 21 eosinophils/HPF,≤ 50 eosinophils/HPF,and ≤ 100eosinophils/HPF.The optimal cut-point was then defined as the candidate cut-point with the largest absolute difference.SPSS 24.0 software was used to analyze the data.Results When the tissue Eos grouped by 50 eosinophils /HPF,the VAS,nasal sinus CT,endoscopic preoperative score,and the endoscopic postoperative score at 3 months and 6 months showed significant difference(The P values were much smaller than 0.05).The tissue Eos between skin prick test(SPT)positive group and SPT negative group showed no significant difference(P>0.05).The peripheral Eos between skin prick test(SPT)positive group and SPT negative group showed statistically significant difference(P<0.05).The tissues Eos was sighificantly correlated with the peripheral Eos(P<0.01,r =0.459;P<0.01,r =0.473).Conclusion The most meaningful cutoff point may be 50 eosinophils /HPF nearby to distinguish ECRS and non-ECRS(taken nasal polyps,by random HPF).The allergic factors may didn’t leading important role for the rise of tissue Eos in the CRSs NP patients,but it may have effect on peripheral Eos.The peripheral Eos may be an indicator of the level of the tissue Eos.