Clinical Study On The Effect Of Buyang Huanwu Decoction On Serum MBP In Patients With Acute Spinal Cord Injury

Objectives:The effect of Buyang Huanwu Decoction on serum MBP in patients with acute spinal cord injury was investigated by using the method of Buyang Huanwu Decoction in patients with acute spinal cord injury.The ASIA sensation,exercise score and grade synchronization were compared with the patients.The relationship between MBP content and the improvement of neurological function in serum of Buyang Huanwu Decoction was to find a new treatment plan and clinical reference index for postoperative functional recovery in patients with acute spinal cord injury.Methods:60 patients with acute spinal cord injury who were treated by spine surgery from March 2015 to May 2016 were randomly divided into experimental group and control group.All the subjects included in the study were treated with 72 hours after trauma.Emergency or subacute open reduction and decompression and internal fixation.All subjects were given routine treatment of dehydration,hormones,anti-inflammatory and neurotrophic drugs.The experimental group in the above-mentioned conventional treatment on the basis of the first day after the start of taking yang orang decoction,a daily dose,taking 12 weeks.All subjects were routinely trained during hospitalization and continued to receive relevant rehabilitation after discharge at 4-5 weeks postoperatively.The sensory motor function and self-care ability of all subjects were evaluated by ASIA score scale,preoperative,postoperative 28 days and 12 weeks postoperatively.The levels of MBP in the serum of the subjects were measured by enzyme-linked immunosorbent assay To be measured Data were analyzed by SPSS20.0 statistical data.All the data were recorded in the mean/standard deviation(X ± S).The gender,age,injury segment,course of disease and degree of injury were analyzed.The t-test and variance analysis were used to analyze the data.The rank-sum test was used to analyze the non-normal data.The X2 test was used to analyze the count data.P<0.05 showed a statistically significant difference.Results:To comparison in group,the experimental and control groups’ ASIA sensorimotor score,FIM score of 28 days after surgery and 12 weeks after surgery,and latency of SEP and MEP of 12 weeks after surgery compared with pre-operation were both significantly improved.In 28 days after surgery,the ASIA sensory score and FIM score compared with pre-operation was no significant difference(P>0.05),and the ASIA motor score compared with pre-operation was statistically significant(P<0.05).In 12 weeks after surgery,to experimental group,there was a significant difference on ASIA sensory and motor score,FIM score between the three time points(P<0.05),also the latency of SEP and MEP compared with pre-operation was significantly different(P<0.05).To control group,there was no significant difference on ASIA sensory score and FIM score between the three time points(P>0.05).However there was a significant difference on ASIA motor score between the three time points(P<0.05),and the latency of SEP and MEP compared with pre-operation was significantly different(P<0.05).To comparison among group,there was no significant difference on ASIA sensorimotor score,FIM score and latency of SEP and MEP between the 2 groups of subjects before the operation(P>0.05),which was comparable.In 28 days after surgery,there was no significant difference on ASIA sensory score and FIM score between the 2 groups of patients(P>0.05),but ASIA motor score between the 2 groups was was significantly different(P<0.05).In 12 weeks after surgery,there was also no significant difference on ASIA sensory score and FIM score between the 2 groups of patients(P>0.05),nevertheless there was a significant difference on ASLA motor score and latency of SEP and MEP(P<0.05).Conclusion:1.Buyanghuanwu Decoction has a better effect on sensory motor function score and ASIA grade in patients with acute spinal cord injury.2.Application of Buyang Hu,anwu Decoction can significantly reduce the serum MBP in patients with early.The degree of MBP in early serum was correlated with the degree of postoperative functional recovery in patients with acute spinal cord injury.