Study On The Law Of "Syndrome-Treatment-Effect" Of Jaundice Disease Based On Data Mining

Objective This study explores the methods of retrospective medical research by using the data of hospitalized medical records of previous patients with jaundice in Hubei Provincial Hospital of Traditional Chinese Medicine.The core prescription,commonly use drugs and compatibility rules for the treatment of jaundice are studied.Study on the Law of Effectiveness.For the Chinese medicine on the clinical diagnosis and treatment of jaundice and provide ideas and basis.Methods From the retrospective medical records that have been scaned into the image format,the medical records of Chinese medicine diagnosed with jaundice from 1960 to 1978 are screened out.The medical records must be treated mainly with Chinese medicine and have relatively complete medical records,including: Admissi on records,Duration Record,Prescription information of Chinese medicine,Check information and so on.Exclusion of traditional Chinese medicine diagnosis and treatment information is not com plete,no traditional Chinese medicine treatment and death of medical records.Establish a database using an electronic medical record system for medical records that meet the inclusion criteria.The data of the Symptoms,Signs,Tests,Examinations,Medical advice and other information to standard-ize,structured input,the data pretreatment,the use of clust-ering analysis,complex networks and other data mining methods and statistical methods,mining a nalysis of jaundice syndromes Characteristics,core prescription,eff icacy characteristics.Results1.Descriptive analysis of data1.1 Analysis of general information In this study,there were 520 cases of Chinese medicine dia-gnosed with jaundice from 1960 to 1978,among which there were278 cases in 1961-1969 and 242 cases in 1970-1978.Among them,389 were male patients,Accounting for 74.81%.131 patients were female,Accounting for 25.19%,male-based;Which the youngest13 years old,the oldest 78 years old,mainly concentrated in the age of 15-50 years old,mainly young,middle-aged;calculate the patient’s hospital stay,Which the shortest hospital stay 7 days,the longest stay in 235 days,the hospital stay mainly concentrated in 29-40 days.1.2 Diagnostic characteristics of the situation In this study,all the medical diseases included in the dia-gnos is of jaundice were diagnosed as fever,cold,accumulation,exoge nous fever in 7 cases;syndrome diagnosis was Mainly yellow(516 cases),Less yellow(4(40 cases),Early cirrhosis(16 cases),Ac ute jaundice type of infectious hepatitis(14 cases),Chronic(1)cases of acute jaundice hepatitis(409 cases),followed by jaundice hepatitis Hepatitis(13 cases)and so on.Can be seen in this study included jaundice for liver-derived jaun-dice,which is mainly for acute jaundice hepatitis as the main manifestation of acute hepatitis.But also contains 67 cases of chronic liver disease,Such as schistosomiasis,chronic heap-titis,cirrhosis and so on.1.3 previous disease analysis In the inclusion of jaundice medical history,the previous history of liver disease in 123 cases,there are other history of 7 cases.1.4 General analysis of drugs There were 327 Chinese herbs used in 520 cases of jaundice.The first 30 Chinese herbs were selected as:Yinchen(2485),Poria(2157),Turmeric(1552),Ginger gardenia(1398),Tangerine peel(1327)(978),Fried malt(932),Angelica(911),Fried bud(908),Salvia(902),Alisma(853),Jiang Hongbao(766),Fried Atractylodes(7),Licorice(646),Coix seed(611),Rhubarb(602),Patrinia(583),Pla ntago(574),Plantago(482),North(473),Baicalin(473),Talcum powder(446),Cork(446),Rhizoma Imperatae(420),Radix Isatidis(410),Pinellia ternata(391),Fried fruit(389)380).A total of 19 cate gories of traditional Chinese med-icine,which diuresis Diuretic drugs,Heat medicine,Tonic drugs used in the first three frequency,The use of high frequency: Qi medicine,Blood circulation drugs,Dige stion drugs,the use of similar frequency;Then other drugs are:Phlegm drugs,Hemo-static drugs,Dampness drugs,Solution drugs,Antiperspirants,Diarrhea drugs,Pinggan Xifeng medicine,Rheum atism drugs,Open surgery drugs,Astringent medicine,Insects,Inse cticide insec-ticide antipruritic drugs used at least.Drugs followed by the highest frequency of the Spleen,Liver,Lung,Stomach and gall-stones.This stage of the prescription drug taste concentrated in the 10-12 taste between the prescription is more streamlined.Chinese medicine used in the dose is basically in line with theprovisions of the safe use of the state,most of the drug doseis more stable.2.Clinical features analysis2.1 Overall symptom distribution A total of 121 symptoms,Systemic symptoms and gastrointest-inal symptoms,Common systemic symptoms are: Fatigue(2795),Urine yellow(2756),Both eyes are(1849),Hypochondriac pain(1143),Insomnia((348),Dizziness(361),Yellowish(340),Bitter(210),Chest tightness(178),Fever(154),Skin itching(139),Lower extremity edema(34)(2364),Abdominal distension(1874),Nausea(704),Loose pond(635),Mouth thirst(334),Cough(33),Headache(32),Other symptoms(90)349),Tired oil(289),Vomit-ing(278),Const ipation(239),Dry stool(230),Abdominal pain(149)and so on.Basi cally consistent with the symptoms of liver jaundice distribution.2.2 Tongue Pulse distribution(2647),Mossy(467),Thick moss(120),Thick greasy(113),Thick moss To white(2583),Moss yellow(1398),Moss yellow(42)based.Suggesting that the disease to wet card,Heat-based.(349),Pulse(741),Pulse number(205),Pulse slip(161),and so on.2.3 Crowd division According to the community divided into five groups of people,each module contains the number of patients were 255,142,91,27,5 cases.According to the chi-square test,The symptoms and signs of each group were compared and found that the first group of people is more obvious heat,The second group of people with less heat,The third group of people to consider the bile Yuyu card,The fourth group of people between the sun Between the yellowand yellow,The fifth group of people dampnes heavier,consider the shade yellow.(1)The first group of specific symptoms and signs are:Moss y ellow,Thin fur,Mouth thirst,Greasy moss,Mouth bitter,Pulse number,Fever,Thirsty do not drink,Thirst hi drink,Thick Greasy moss,Pulse thin,Upset,Cough,Throat and so on.The performance of all the hot and humid like,But the performance of the heat as the most important.The core side of the composition is: Capillaris,poria,Gardenia,Turmeric,Dried tangerine peel,White peony root,Alisma,Salvia,Angelica,Bran fried Atractylodes,Fried malt,Fried buds.(2)The second group of specific symptoms and signs are:Red tongue,White fur,Yellow bright,Yellow,Thick greasy moss,Moss yellow,Thin,Insomnia,Greasy moss,Dry stool,Mouth thir-sty,Mouth Bitter,Pulse number,Pulse slow,Edema,Chlorosis,Thirsty to drink,Thirsty cold drink,Thirsty hi drink,Pink tongue,Cold and so on.Can be seen that the performance of these patients are h ot and humid like,But the heat as light,mainly wet.The core of the composition is: Capillaris,Poria,Fried Atractylodes,Turmeric,White peony root,Alisma,Gardenia,Dried tangerine peel,Fried rice buds,Fried malt.(3)The third group of specific symptoms and signs are: White fur,Red tongue,Yellow and bright,Mouth thirst,Hypochond-riac pain,Pulse slow,Dry stool,Mouth bitter,Chest tightness,Dizziness,Thirsty cold drink,Drink,Apathetic,Dry when dry when thin,Pulse thick,Thick fur,Thin body weight,Pale tongue,Insomnia,Little moss,Yellow urine,Stomach abdominal swelling of the liver boring,Backache,Moss yellow,Depending on the material is unclear,Teeth bleed at the nose,eyes,mouth sweet and so on.Can be seen in such patients Yu heat like the more obvious,Hypochondriac pain,Chest tightness symptoms,in order to consider the courage for the heat syndrome.The core side of the composition is Ca pillaris,Poria,Turmeric,Gardenia,White peony root,Salvia,Dried tangerine peel,Fried rice buds,Fried malt,Fried magic song,An gelica and so on.(4)The fourth group of specific symptoms and signs are: Tongue pink,White fur,Pulse thin,Insomnia,Apathetic,Lower extre mity edema,Pulse weak,Yellow,Tingling,Frequent urination,Lower limb pain,Lower limb pain,Palpitations,Spontaneous perspirati on,Dysuria and so on.It can be seen that such patie-nts can not distinguish between yin and yellow,between yin and yang.The core side of the composition is Poria,Capillaris,Turmeric,Tanger ine peel,Salvia,White peony,Gardenia,Angel-ica,Fried rice buds,Fried malt,Fried magic song.The core side of the composition is Poria,Capillaris,Turmeric,Tangerine peel,Salvia,White peony,G ardenia,Angelica,Fried rice buds,Fried malt,Fried magic song.(5)The fifth group of people,Including the least patients,only5 cases,because the symptoms contained less,so all the sympt oms and signs listed.Which contains tired of oil,Moss white,A pathetic,Yellow dull,dusk,Moss yellow,Thick fur,Thin tongue,Tongue,Red tongue,Dry stool,Loose stools,Chest tightness,Chil ls,Pink tongue,Skin itching,No blonde,Pulseand other symptoms and signs,Showing the symptoms of yin yellow.The core party group is capillaris,Poria,Magnolia,Herb,Car-damom,Gardenia,Tur meric,Dried tangerine peel,Talc,Fried rice buds,Fried malt,Sal via.2.4 Analysis of efficacy2.4.1 Chinese medicine on jaundice symptoms and signs of the impact The number of positive symptoms and signs of the symptoms and symptoms of the course of the course of disease,the cours eof the course of the disease,the median duration of the disease,the number of positive symptoms and symptoms of the course of the disease,frequency,frequency comparison,found in the middle,The last course of disease also decreased significantly,Appear whe n the hospital did not appear symptoms,signs,but also from the side to reflect the majority of jaundice by traditional Chinese medi cine treatment,the disease has been effectively controlled.2.4.2 based on liver function index analysis Statistical analysi of jaundice index,bilirubin and alanine aminot ransferase in patients before and after treatment.The Pvalue was significantly less than 0.00,with significant stat-istical significance.Jaundice patients in the system after the treatment of biochemi cal indicators have been significantly improved,to prove that Chinese medicine in the enzyme,yellow-ing has a better effect.3.Core-based extraction based on valid medical records We lowered the jaundice index as criterion for determining the validity of the disease.And finally into the effective med-ical history of 479 cases,The corresponding Chinese medicine side has 3086.We were based on the information of the effective medical reco rds of the community division,Made a meaningful 10 categories,all types of prescriptions included in the order: 684,607,579,386,276,174,120,38,30,24.The We use multi-layer complex network were extracted from the various types of prescr-iption module core drug composition.(1)The core of the module 1 drugs:Capillaris,Poria,Alisma,Ga rdenia,Plantain,Dried tangerine peel,Turmeric,Fried Atra-ctylodes,Rhubarb,Polyporus,Magnolia,Radix.For the capillaris Artemisia mixed with four Ling powder addition and subtraction.(2)Module 2 core side of the drug composition: Capillaris,Turmeric,White peony root,Patrinia,Poria,Salvia,Dried tangerine peel,Cyperus rotundus,Angelica,Coix Seed,Gardenia,Plantain,B anlangen,Gentian.(3)Module 3 core drugs are: Angelica,Salvia,Turmeric,Po ria,Capillaris,Qingpi,Bupleurum,Dried tangerine peel,Whi-te peony,Fried Atractylodes,Fried rice buds,Fried malt,Gar-denia.(4)Module 4 core drug composition:Capillaris,Poria,Alisma,Fri ed malt,Fried rice buds,Gardenia,Turmeric,Fried magic song.(5)Module 5 core drug composition: Capillaris,Poria,Fried ma gic song,Magnolia,Talcum powder,Dried tangerine peel,France Pinellia,Licorice.(6)Module 6 core drug composition: Rhubarb,Mirabilite,Ga rdenia,Cork,Citrus aurantium,Magnolia,Capillaris.(7)Module 7 core drug composition: Poria,White peony root,Peony skin,Codonopsis,Licorice,Turmeric,Scutellaria.(8)Module 8 core drug composition: Artemisia annua,Gentian,Rhubarb,Fried malt,Fried rice buds and so on.(9)Module 9 core drug composition:Sea gold Savine,Plantain grass,Artemisia annua,Money grass,Honeysuckle,Brown sugar.(10)Module 10 core drug composition: Plantain grass,Capil-laris,Red Poria,Chicken gold,Gardenia,Reed rhizome,Divine Comedy,Citrus aurantium.Conclusion Through the method of data analysis,the study of retrospec-tive inpatient medical records has been explored,and the expe-rience has been accumulated for the retrospective study.Throu-gh the use of data mining methods,analysis of the jaundice history of the five groups of people,all kinds of specific sym-ptoms and sig ns of the crowd and the core prescription,and exploratory accor ding to biochemical indicators of jaundice history of the efficacy of the analysis,based on the effective medical records of the divisi on of prescriptions,Extract 10 categories of core side.Through the study of "card-cure-effect" in the treatment of jaundice in 19 y ears in Hubei Province,It can be seen that although this period is in the low period of academic research,it still shows a relativel y high level of diagnosis and treatment in the treatment of jaundice.The period of treatment of jaundice academic experience is heat a nd dampness balance,never forget blood and detoxification,atten tion to spleen and liver,righting and Quxie co-application.Followed the evening to the Republic of China attention from the blood poi nts,hepatobiliary spleen to start the diagnosi and treatment of jaun dice,and modern Chinese medicine treatment of jaundicesimilar to the theory that this period of treatment of jaundice has been more mature and comprehensive.The results of this study can also provide some ideas for the clinical treatment of jaundice disease.