Study On Influence Of Subclinical Hypothyroidism On Lipidemia And MPV And Correlation With The Severity Of Coronary Artery Lesions

Objective: To understand effects of subclinical hypothyroidism(SCH)on lipidemia and MPV,and to further investigate its relationship with severity of coronary artery lesions in coronary heart disease(CHD).Methods: This was a retrospective study.Data of 310 subjects who made a diagnosis of CHD by coronary arteriography first time at the department of cardiology from June 2015 to December 2015 were analyzed.Subjects were divided into two groups as SCH group(n=93)and normal group(n=217),based on thyroid function test.We recorded the results of examination and coronary arteriography,and divided subjects into different groups,according to lesion vessel numbers and Gensini score of coronary disease.Collecting general clinical patients’ data,measured their blood biochemical indicators on the second morning: and analyzed the relationship between subclinical hypothyroidism and coronary artery lesions.Results: Severe SCH group had a higher level of blood lipids(TC,LDL,LP(a),ApoB),CYC-C,MPV,Gensini score than the mild SCH group and normal thyroid function group,had a higher level of TG than the normal thyroid function group(P<0.05).The mild SCH group had a higher level of TC and MPV than the normal thyroid function group(P<0.05).Multi-vessel lesions group had a higher level of the morbidity of SCH than the single lesion group,(P<0.05).SH group,according to Gensini score divide into three groups,We found C group were higher than A and B group In the aspect of TSH and BUN,At the same time,the C group had a higher level of blood lipids(TC,LDL,LP(a)),MPV,CYC-C than A group(P<0.05).Conclusions:1.The severe SCH group had a higher level of blood lipids and MPV than the mild SCH group,severe SCH more seriously(TSH≥10mIU/L)influence on lipid disorders than mild SCH.Multi-vessel lesions group had a higher level of the morbidity of SCH than the single lesion group,(P<0.05).Multi-vessel lesions had a higher level of TSH levels than single-lesion group.the TSH level is higher,the Gensini score is higher and coronaryartery lesions in the range,the greater the degree of stenosis is heavier.