Correlation Research Between Subclinical Hypothyroidism On HCY And Left Ventricular Function In Patients With Coronary Heart Disease

With greater sensitivity of assays and more frequent assessment of serum thyroid-stimulating hormone(TSH),there is a rise in the prevalence of subclinical hypothyroidism(SCH).SCH has become a attractive research hotspot due to potential hazards.Objective: 1.To analyze the effect of subclinical hypothyroidism(SCH)on serum homocysteine(HCY)level,blood lipid profile,left ventricular structure and function,and the severity of coronary stenosis in patients with coronary heart disease.2.To explore the relationship among the serum thyroid-stimulating hormone(TSH)levels,HCY levels,and coronary stenosis severity in coronary heart disease patients with subclinical hypothyroidism.Methods: In this retrospective analysis,data from inpatients at General Hospital of Ningxia Medical University from May.2014 to May.2017 were collected.The coronary artery disease was diagnosed coronary angiography.The patients with subclinical hypothyroidism was case group,and the patients with euthyroidism was control group.The data included age,gender,diagnosis,height,weight,past history,coronary angiography results,thyroid function,HCY,total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),cardiac ultrasound findings,etc.Subgroup analysis of case group was based on serum TSH levels,and the relationship among TSH levels,HCY levels,the severity of coronary lesions(Gensini score)was compared between the two subgroups.Result:1.In the case group,there were 44 female patients,accounting for 61.1% of allpatients with SCH,and 28 patients were male patients,accounting for 38.9% of all patients with SCH.2.There was no significant difference in age,sex,body mass index(BMI)between case group and control group(P>0.05).3.Compared with the control group,the TC,TG,and LDL-C levels were higher in the case group(P<0.05),but there was no significant difference in HDL-C levels(P>0.05).4.The HCY level in the case group was higher than that in the control group(P<0.05).5.Left ventricular diastolic function in the case group was statistically different from that in the control group(P<0.05),but there was no significant difference in left ventricular systolic function(P>0.05).6.The Gensini score of coronary artery lesions in the case group was higher than that in the control group(P<0.05).7.There were differences in serum HCY levels between the two subgroups.(P<0.05),but there was no statistical difference in TG,TC,HDL-C,LDL-C,left ventricular end diastolic diameter,left ventricular systolic diameter,and ejection fraction(P >0.05).8.Serum TSH concentration was positively correlated with HCY(r=0.464,P<0.05).9.Serum TSH concentration was negatively correlation with E/A ratio(r=-0.200,P<0.05);No significant correlation between TSH concentration and EF value(r=0.011,P>0.05).10.Serum TSH concentration was positively correlated with the severity of coronary lesions(r=0.387,P<0.05).Conclusion:1.There were differences in serum lipid levels between subclinical hypothyroidism and normal patients.2.There was a positive correlation between TSH concentration and HCY level.With the increase of TSH concentration,the level of HCY also increased.3.Coronary heart disease patients with subclinical hypothyroidism have decreased left ventricular diastolic function.