| Aim:Recently,the main methods for Cancer treatment include surgery,radiotherapy and chemotherapy,targeted therapy,biological immunotherapy and traditional Chinese medicine et al.Chemotherapy as an important method for cancer treatment can suppress growth of some tumors and extend patients’ lives.However,chemotherapy drugs have many side effects such as hematological toxicity,gastrointestinal toxicity,organ toxicity damage,hair loss,phlebitis and Some studies have shown that gastrointestinal toxicity is associated with intestinal flora imbalance.In order to figure out the effect of chemotherapy to intestinal microflora and to provide some basis for the application of microecological agents to prevent,alleviate and treat the chemotherapy induced diarrhea(CID),the intestinal flora of patients with tumors who undertake chemotherapy was detected by quantitative analysis.In this study,three representative strains of Bifidobacterium,Escherichia coli and Fusobacterium were selected for further study.All patients were divided into two groups: one is control group which treated with chemotherapy alone and the other is experimental group which treated with chemotherapy combined with Bifidobacterium.The changes of these three were quantified by fecal culture before and after chemotherapy.By comparing the number of Bifidobacterium,Escherichia coli and Fusobacterium before and after chemotherapy in the control group,we could find out whether chemotherapy would affect the balance of intestinal flora.By comparing the number of Bifidobacterium,Escherichia coli and Fusobacterium after chemotherapy between control group and experimental group,we could figure out whether administration of microecological regulators could prevent or reduce the chemotherapy induced diarrhea or other intestinal side effects,which finally help increase the completion rate of chemotherapy,improve the level of treatment,and extend patients’ lives.Methods: 1.Grouping: One hundred and fifteen patients with stage Ⅳ malignant tumor who received chemotherapy were recruited from January 2015 to October 2016 in People ’s Liberation Army 210 Hospital.All of these patients include 38 cases of lung cancer,16 cases of gastric cancer,30 cases of breast cancer,5 cases of esophageal cancer,5 cases of esophageal cancer,7 cases of pancreatic cancer and 19 cases of colorectal cancer.The chemotherapy regimens were IP,DP,DCF,XT,TXT,FOLFOX,FOLFIRI or XELOX.The patients were randomly divided into two groups: 59 patients as experimental group and 56 patients as control groups.The experimental group was administrated Bifidobacterium live mushroom capsules.All patients had no history of administration of antibiotics or other gastrointestinal diseases.All patients received no less than four cycles chemotherapy.2.Specimens: The stool specimens of all patients were collected before the first cycle of chemotherapy,before the fourth cycle of chemotherapy,and the 7th and 14 th day after the fourth cycle of chemotherapy.By using the improved culture medium and culture identification method,the quantitative of Intestinal flora was analyzed.Result: By detecting the number of bifidobacteria,Escherichia coli and Fusobacterium in the fecal samples of patients we found that after three cycles chemotherapy the number of bifidobacteria,Escherichia coli was significantly reduced and the number of Fusobacterium was increased in the control group.In the experimental group,administration of Bifidobacterium live mushroom capsules could reduce the symptoms of gastrointestinal toxicity such as diarrhea,abdominal pain,constipation.The difference was statistically significant.But the intestinal flora had no difference compared with control group.Conclusion 1.Chemotherapy inhibit the growth of normal intestinal flora and aggravate the imbalance of intestinal flora.2.Administration probiotics during chemotherapy could help keep the intestinal flora balance,reduce the degree of intestinal flora imbalance and reduce gastrointestinal reactions and intestinal mucosal inflammation. |
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