Expression Of Notch1 In Esophageal Squamou Cell Carcinoma And Its Clinical Significance

Objective In this study,immunohistochemistry was used to detect the expression of Notch1 and lymph node metastasis in esophageal squamous cell carcinoma and adjacent normal tissues,and to explore the correlation between the expression of Notch1 in each group;and clinical follow-up of survival rate of Notch1 expression in each group.To determine whether Notch1 can be used as a molecular marker related to esophageal squamous cell carcinoma.Methods1.A group of 100 patients with esophageal squamous cell carcinoma were collected as the experimental group,and another group of 40 cases of normal esophageal tissues were selected as control group.The expression of Notch1 in each group was detected by Eli Vision immunohistochemical method.2.The expression of Notch1 protein positive group and negative group was correlated with lymph node metastasis.3.The 2 year survival rate of the patients was calculated,and the survival difference between Notch1 positive group and negative group was compared.Results1.The expression of Notch1 in esophageal squamous cell carcinoma tissues was significantly different from that in normal tissues(P<0.05),and the expression level of Notch1 was significantly lower than that of normal esophageal mucosa tissues.2.The expression of Notch1 protein was negatively correlated with lymph node metastasis,and the difference was statistically significant(P<0.05).3.The survival rate of Notch1 positive group was significantly lower than that of Notch1 negative group,the difference was statistically significant(P<0.05).Conclusions1.Notch1 may play an important role in inhibiting the growth of esophageal squamous cell carcinoma.2.Patients with high expression of Notch1 protein in esophageal squamous cell carcinoma patients were less likely to have lymph node metastasis compared to patients with lower expression of Notch1 protein,and the expression of Notch1 protein was negatively correlated with lymph node metastasis.3.The expression of Notch1 protein may be correlated with the prognosis and survival of patients.