The Relationship Between Thyroid Hormone Levels Within The Reference Range And ISR For Coronary Disease:An Angiographic Study

Objective:Coronary artery disease is a major cause of mortality and morbidity worldwide.Percutaneous coronary intervention(PCI)has become a very important and effective treatment for coronary heart disease(CHD),and it has been proved to be a safe and effective treatment technology,but In-stent restenosis(ISR)is still the most concerned problem.It has been studied that even normal range of thyroid hormone levels are associated with CHD.To study the correlation between normal level of thyroid hormone and Restenosis after stent implantation of CHD.Methods:Here we enrolled 249 patients with CHD who were accepted PCI during first admission.At 6～12 months after stent implantation,all of the patients were administered coronary angiography to evaluate ISR.According to whether ISR was detected,patients were divided into two groups:the ISR group(n=93)and the non-ISR group(n=156).Serum thyroid hormone levels was assessed at first admission in all patients.Their thyroid hormone levels within reference range were compared and correlation between thyroid hormone level and ISR was studied.The data obtained in this paper for statistical processing and analysis,using spssl9.0 statistical software for data processing,count data using chi square test,measurement data to(x±s)said,measurement data using t-test and multiple groups were compared with single factor analysis of variance,multiple comparisons with LSD-t method,P<0.05 for the difference has statistical significance.Results:Baseline characteristics of the two groups were similar.Patients in the ISR group had significantly lower four iodine thyroid(T4)levels compared with patients in the non-ISR group at admission(P<0.05,respectively).Furthermore,the ISR group had significantly more stents compared with the non-ISR group(P<0.05,respectively).In a multivariate analysis,T4 levels was associated independently with ISR.Conclusion:The serum T4 level is lower in CHD patients with ISR than in CHD patients with non-ISR,which may be an independent risk factor associated with ISR..