CD44 And CD90 Are Associated With Survival In Patients With Liver Transplantation For Primary Hepatic Carcinoma

Aims: To investigate whether CD44 and CD90 could be effective prognostic markers in patients with liver transplantation for primary hepatic carcinomas.Material and methods :trospective cohort study included a total of 105 patients with HCC, who underwent liver transplantation at a single center, from 2001 to 2012.Demographic features and clinicopathologicaldata, expression of CD44 and CD90 by immunohistochemistry, and long-term survival rates were analyzed, and the prognostic impact of the individual factors, together with standard histologic parameters, was calculated by univariate and multivariate analyses.Results:1. CD44, CD90 expression in liver transplantation for hepatocellular carcinoma cancer rate of 60.1%, 50.5% were highly expressed. By the Spearman correlation analysis, the expression of CD44 and CD90 have correlation(P < 0.001), and a positive correlation(r= 0.496), CD90 and CD44 high co expression of 36.5%, CD44 and CD90 low expression of 63.5%.2. CD44, CD90 expression and the clinicopathological features: CD44 in cancer tissue of liver transplantation for hepatocellular carcinoma, CD90 expression in age, gender,tumor number, tumor site differences no statistical significance(P > 0.05). And the differentiation degree, preoperative AFP level, tumor diameter, micro vascular invasion have significant difference(P < 0.05).3. Kaplan-Meier univariate analysis showed that tumor size, preoperative AFP, degree of differentiation, vascular invasion, CD44, are the risk factors affecting the prognosis of co expression of CD90 and CD44 and CD90(P< 0.05). The patients’ age, gender,tumor number, tumor site was not statistically significant(p>0.05) analysis showed that high expression. CD44, patients with low expression and high expression of CD44CD90 and the low expression of CD90 in patients with liver resection after their 5 year survival rates were significantly different(15.7VS65.3%)(P<0.001) /(13.0VS66.5%)(P<0.001) Kaplan-Meier analysis showed that CD44 and CD90 high expression than patients with CD44 or CD90 low expression patients after the 5 year overall survival rate was significantly lower and the expression of.CD44 and CD90(10.7VS54.5%)(P<0.001).COX multivariate analysis showed that tumor diameter, preoperative AFP,degree of differentiation, vascular invasion, CD44, CD90, CD44 and CD90 co expression is the long-term survival of patients Independent risk factor(P<0.05).Conclusions: CD44, CD90 and CD44 and CD90 expression and of liver transplantation for hepatocellular carcinoma in patients with postoperative survival rate; CD44, CD90 is independent risk factors influencing survival in postoperative patients with liver transplantation for hepatocellular carcinoma can be as a predictor in predicting prognosis in patients with liver transplantation.