Noninvasive And Quantitative Assessment Of Liver Lesions In Patients With Chronic Hepatitis B Using Fibro Scan Controlled Attenuator Parameters

Purpose: This study was to non-invasively and quantitatively assess liver inflammation, fibrosis and fatty degradation in patients with chronic hepatitis B(CHB) using Fibro Scan Controlled Attenuation Parameters(CAP).Materials and Methods: Fibro Scan and liver biopsy were performed in 80 patients with CHB. The sensitivity and specificity of CAP values for the prediction of liver lesions were evaluated using t test, correlation and ROC curve analysis.Results: The CAP values in patients with chronic hepatitis B were negatively correlated with inflammation grades and fibrosis stages((r=-0.34,p<0.05). There was significant positive correlation between CAP values and liver fatty degradation(r=0.4197, p<0.01). CAP values were significantly different between mild and moderate-severe inflammation and fatty degradation(p<0.05). The area under ROC curve of CAP values for inflammation(G<2 vs G≥2), fibrosis(S<2 vs S≥2) and fatty degradation(F<2 vs F≥2) was 0.8405, 0.8205 and 0.9101, respectively. Cut-off value of194 d B/m could detect moderate-severe inflammation with sensitivity of 81% and specificity of 89%. Cut-off value of 236 d B/m could detect moderate-severe fibrosis with the sensitivity and specificity of 79% and 85%,respectively. Cut-off value of 267 d B/m could distinguish mild fatty degradation(F<2) from moderate-severe fatty degradation(F ≥ 2) fibrosis with the sensitivity and specificity of 85% and 91%, respectively.Conclusion: Fibraoscan CAP values could distinguish mild and moderate-severe liver inflammation, fibrosis and fatty degradation and could be used for quantitative evaluation of liver lesions as the alternate of liver biopsy.