Clinical Observation Of Treating Acute Gouty Arthritis By Selecting Drug According To The Thinking Of Identifying The Guijing Properties Of Disease

Objective: According to the thinking of identifying the Guijing properties of disease to select drugs proposed by Guanjinghuan,using the modern common prescription Dangguiniantongtang which was for the treatment of Acute gouty arthritis as the basic prescription, then forming a new prescription which called Guijing-dangguiniantongtang carried out by this theory. To observe the clinical observation of treating Acute gouty arthritis, trying to distinguish if there were some advantages of this thinking for clinical validation.Methods: All patients were from Wuhan Integrated TCM and Western Medicine Hospital Division of Rheumatology clinic. Selecting 78 patients with acute gouty arthritis in line with Western medicine and TCM diagnostic criteria, were randomly divided into two groups, the treatment group(Guijing-dangguiniantongtang group) had 40 cases, including 34 males and 6 females, in the control group(Dangguiniantong group) had 38 cases, 32 cases were male and 6 females. Two groups of patients were theated by the same TCM principles, on the basis of general treatment, the control group was given the Dangguiniantong, and the treatment group to go through Guijing-dangguiniantong Treated, both were treated for 4 weeks. Collecting relevant clinical data before and after treatment, such as the total clinical efficacy, the main symptom scores, serum uric acid(SUA), serum creatinine(Scr), white blood cell count(WBC), C-reactive protein(CRP), erythrocyte sedimentation rate( ESR) and other metrics. Using SPSS 17.0 software for statistical analysis, all data were means((?)±s), count data using chi-square(χ2) test, measurement data using paired t test, comparison between groups two-sample using t test, ranked data with Ridit test, significance level set α=0.05.Result:1. In terms of the total clinical efficacy of the treatment group, 10 patients were cured, 19 patients were cured, 8 cases effective, 3 cases ineffective, the total response rate was 92.50%. in the control group, 7 patients were cured, 16 patients were cured, effective 11 patients, 4 patients invalid, the total response rate was 89.48%. The difference was not statistically significant(P﹥ 0.05),indicating that the treatment group and the control group had clinical outcomes, but they were not better than each other.2.In the comparative clinical symptom scores, the two groups of patients major symptom scores were significantly reduced after treatment, the difference was statistically significant(P ﹤0.05). And the treatment group even more sharply reduced compared to the control group, the difference was significant(P ﹤0.05). It showed that the treatment group and control group can effectively alleviate the clinical symptoms, but the effect of the treatment group was more significant than the control group.3.In terms of reduction of serum uric acid levels, after two groups of patients with treatment serum uric acid level has dropped significantly, and the difference was significant(P ﹤0.05). It was compared between the two groups after treatment, the difference was statistically significant(P ﹤0.05). That both approaches can reduce blood levels of uric acid, and the treatment group was better.4.In other biochemical indicators, after treatment, both groups of patients and inflammatory markers in serum creatinine before treatment decreased, and the difference was statistically significant(P ﹤0.05), but no significant difference between two groups after treatment, was not statistically significant(P ﹥0.05). It showed that two drugs can effectively inhibit the acute inflammatory response and improve renal function to some extent, and no significant difference in the efficacy of the two schemes.Conclusion:1.Treating Acute gouty arthritis by selecting drug according to the thinking of identifying the Guijing properties of diseas had no obvious advantages, but in the acute phase relieve joint pain, swelling, dysfunction symptoms, lower blood uric acid levels, etc. were better than the original parties, indicating that this thinking may have some clinical advantages in some areas.2.If the thinking of identifying the Guijing properties of disease to select drugs in samples of other large-capacity and more than one kind of disease study can come up with a similar conclusion of this study needs further research to prove it.