| Objective:The subject treated by the observation of clinical symptoms and side uric acid laboratory Indexes liver and spleen deficiency hyperuriccmia evaluate the clinical effect revealed under guidance of TCM theory, through syndrome differentiation, to liver and spleen, Huayu the clinical efficacy of dampness uric acid method prescription treatment liver and spleen deficiency hyperuricemia and its mechanism of action, on the one hand to provide an effective therapeutic approach and methods hyperuricemia, on the other hand for the development of the treatment of high uric acid hypcrlipidemia lay the foundation of Chinese medicine.Method:This study is under the guidance of the principles of evidence-based medicine, combining traditional Chinese medicine symptom observation and single-blind, randomized, parallel controlled experimental design. On 56 cases will meet the diagnostic criteria (both from Xiangyang outpatient or inpatient Chinese Medicine Hospital of Endocrinology from June 2015 to March 2016 period) in accordance with the principles of randomized, divided into treatment group (treatment group) and the control group (western medicine group), hereinafter referred to as the treatment and control groups. Treatment group 24 males and 7 females, average age (39.5±13.6) years of age, serum uric acid (SUA) (514.3± 63.20) umol/L; control group,19 males 6 females, average age (39.34±12.90) years, uric acid (510.74±62.50) umol/L. General information between the two groups, the difference was not statistically significant (P> 0.05), comparable. Treatment group was treated drop of urine Spirit, (Chai Hu 10g, yujin 15g, cangzhu 10g, zexie 15g, shengyiren 20g,bixie 20g, fuling 15g, shenghuangqi 15g, danshen 15g, chuanniuxi 15g, Zeeland 15g, cheqianzi 15g, weilingxian 10g, peach kernel 18g, Xiangyang City Chinese Medicine Hospital preparation room),10 pills each time, three times a day; the control group was treated with allopurinol tablets (Guangzhou Baiyunshan pharmaceutical Factory provided), each 100mg,2 times a day. Both groups were to be the basis of treatment, light low-purine diet, sufficient quantities of drinking water.30 days for a course of treatment. Observe the changes in clinical symptom score and serum uric acid during treatment, blood lipids, blood glucose, liver and kidney function, urine,blood and other indicators of the efficacy and safety indicators before and after treatment. After the end of the experiment measurement data as mean standard deviation ((?)± s), said self controlled using t test, count data using the x~2 test between the two groups with Ridit test. Application SPSS19.0 software for statistical data processing and analysis, to arrive at the findings.Result:The treatment group markedly effective rate was 73.3%, total effective rate was 86.2%. Markedly effective rate was 65.3% in the control group, the total effective rate was 77.03% (P> 0.05). Adverse reactions was 12.90% of the treatment group and the control group of adverse reactions was 28.00%. Statistical comparison, total effective rate (x~2 value 2.093), P> 0.05, treatment group and control group considerable effect. Two markedly effective rate (x~2 value 9.451), P<0.05, treatment group than the control group efficacy. Prompted in improving clinical symptoms and signs of improvement, the treatment group than the control group.Conclusion:Uric acid side groups in lowering blood uric acid in patients with considerable control group, but in improving the clinical symptoms and signs is concerned, the treatment is better than the control group. Uric acid side to Chinese medicine theory, in conditioning organs function, through syndrome differentiation, with liver and spleen, stasis dampness for the law, can significantly lower blood uric acid, and no obvious side effects, clinical efficacy, clinical symptoms ease the obvious, there is a high clinical clinical value, as further clinical research and development of new drugs. |
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