Analysis Of 141 No-function Pituitary Macroadenomas’ Clinical Characters

Objective:No-functional pituitary adenomas belongs to one kind of the common types of pituitary adenoma,it is hard to find because of lacking of typical clinical symptomsin time.In the clinical it will be found in the diagnosis of oppression and attack symptoms.Treatment of tumor is difficult to achieve expected results and operation of the cutting rate is low.Knowing no-functional pituitary adenomas clinical data could helpdiagnosing of tumors early,early treatment and relapse not easily.According to the serum level of endocrine hormone and symptoms,it is defined that no-function of pituitary adenomas showed no endocrine related in clinical symptoms,serum endocrine hormone levels in the normal or below normal levels of tumor.This article provide no-function of pituitary adenoma surgery effect,postoperative review and the related factors influencing the recurrence of the tumor,to provided valuable application value in the implementation of the clinical treatment and postoperative review time choice.Methods:141 cases with no-functional pituitary adenomas confirmed by surgery in our hospital with clinical symptoms,the choice of surgical procedure,postoperative patients with complications and recovery situation by reviewing analysis,understanding the hospital neurosurgery for non-functional pituitary adenoma treatment effect will guide clinical treatment.Results:In141 cases of patients,including no invasive large adenomas99 cases(70.2%),invasive large adenoma 42 cases(29.8%).Headache or dizziness 29 cases(20.6%),unilateral or bilateral visual field change was 72 cases(51.1%),there are different levels of pituitary function such as drinks,polyuria,sleepiness symptoms,oppression symptoms tumor oppression frontal temporal lobe including hallucination and emotionaldisorders.Amenorrhoea or menstruation,poor sexual endocrine symptoms of 21 cases(14.9%),15 cases(10.6%)of 141 cases of patients with stroke patients,tumor showing cystic change 38 cases(27%).Tumor with cuting all 118 cases,35 patients with most of the tumor resection.In 19 patients with pituitary function is low,42 patients with postoperative temporary diabetes insipidus,6 patients with permanent symptoms of urinary collapse,14 patients with central low sodium,the hypothalamus symptoms 4 cases,2 cases of cerebrospinal fluid leak,6 patients with the sense of smell is ineffective.Tumor size,tumor invasive pituitary function,preoperative,intraoperative tumor resection degree four factors related with the recurrence of the tumor,with statistical significance(P < 0.05),the tumor size,the greater the risk of postoperative recurrence is higher;Non-invasive tumor recurrence than aggressie tumors;Intraoperative tumor bulk tumor recurrence in patients with high risk;Preoperative pituitary function and the high risk of tumor recurrence of low,while no significant age.According to the size of the regression coefficient judgment,preoperative pituitary function for reducing the role of functional pituitary adenoma recurrence risk biggest,followed by tumor full cut,noninvasive adenomas,the size of the tumor.Conclusion:1.Postoperative complicationswill be less after resection by the nasal-sphenoidal approach,and with using auxiliary endoscopy or navigation technology,large adenoma will be resected well.2.Affectedno-functional pituitary recurrence factors including tumor size,tumor invasive pituitary function,preoperative and intraoperative whether tumor resection and postoperative adjuvant therapy(radiation).Namely the neoplasm,the greater the volume,the higher the risk of postoperative recurrence,Non-invasive tumor recurrence than aggressie tumors;Intraoperative tumor bulk tumor recurrence in patients with high risk;People with poor preoperative pituitary function the high risk of tumor recurrence.Incomplete resection of the tumor and postoperative secondary radiation therapy,improve the cure rate.3.Thestuffing in tumor bed can influence the early use of MRI to determine tumor resection,even so,the early magnetic resonance imaging(MRI)can be compared to earlier identified residual tumor,provide valuable information for later review of magnetic resonance imaging(MRI),the stage of the review of MRI is meaningful.