Trends In The Levels Of Serum Lipids And Lipoproteins And The Prevalence Of Dyslipidemia In Adults With Newly Diagnosed Type 2 Diabetes In Chongqing,China During 2003-2012

Objective:To determine the trends of serum lipid levels and dyslipidemia in adults newly diagnosed with type 2 diabetes mellitus during 2003-2012 in Chongqing, China.Methods:Serum lipid measurements of 994 adults were obtained from 5 independent,cross-sectional studies(2003-2004,2005-2006, 2007-2008,2009-2010, and 2011-2012). The main outcome measures were mean serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride levels; body mass index; hemoglobin A1C level; and the percentages of patients with dyslipidemia, hypertension, coronary heart disease, and cerebrovascular disease.Results:The mean total cholesterol and low-density lipoprotein cholesterol levels increased from 4.92±1.15 to 5.30±1.17 mmol/L (P=0.039) and 2.72±0.83 to 3.11±1.09 mmol/L (P=0.004), respectively, and the mean HDL-cholesterol level declined from 1.22±0.30 to 1.06±0.24 mmol/L (P<0.001). The percentages of patients with dyslipidemia increased gradually as well. The incidence of coronary heart and cerebrovascular diseases increased from 8.2% to 19.1% and 6.6% to 15.3%, respectively (P<0.05).Conclusions:Unfavorable upward trends were observed in serum lipid levels and the prevalence of dyslipidemia, coronary heart disease, and cerebrovascular disease in adults newly diagnosed with type 2 diabetes mellitus in Chongqing,China during 2003-2012.