Expression And Clinical Significance Of Matrix Metalloproteinases-2 In Endometrial Cancer:a Systematic Review

Objective:To investigate the expression significance of matrix metalloproteinases-2 in endometrial cancer with a systematic review.Methods:Databases including PubMed、Medium BIOSIS previe ws、The Cochrane Library (Issue 1,2015)、CNKI、VIP and CBM were electronically searched for retrieving relevant studies on MMP-2 and endometrial cancer, published in foreign and domestic areas fro m inception to April 2015. Meanwhile, relevant journals were also m anually searched. Assessed the quality of included studies and extract ed the data strictly according to the Cochrane Collaboration, and firm aly meta-analysis was conducted.Results:Totally 1573 cases of 15 studies were selected for this Meta analysis. The results of meta-analysis showed that, a) there were significant differences in positive rate of MMP-2 expression between endometrial cancer tissues and normal endometrial tissues [OR=16.24,95% CI 10.63 to 24.82, P<0.00001], endometrial cancer tissues and benign uterine tissues [OR=6.14,95% CI 4.14 to 9.10, P<0.00001], benign uterine tissues and normal endometrial tissues [OR=3.00,95% CI 1.62 to 5.55, P=0.0004]. b) Significant differences were also found between high and moderate/low differentiated tissues [OR=0.59,95% CI 0.43 to 0.80, P=0.0008], endometrial cancer with lymph node metastasis and that without lymph node metastasis [OR=2.29,95% CI 1.30 to 4.04, P P=0.004], endometrial cancer with shallow and deep muscular infiltration [OR=0.27,95% CI 0.16 to 0.44, P<0.00001]. No significant difference was found between clinical stages Ⅰ～Ⅱ and Ⅲ-Ⅳ[OR=0.49,95% CI 0.22 tol.06,P=0.07].Conclusion:MMP-2 expression is significantly correlated to end ometrial cancer and its degree of differentiation, depth of myometrial invasion and lymph node metastasis except clinical stages, which ma y participate in the carcinogenesis of endometrial cancer.