The Experimental And Clinical Research Of Yishenyangyinhuoxue Recipe To Treat PCOS

Purpose This topic is intend to prove the validity of Yishenyangyinhuoxue method to treat polycystic ovary syndrome（PCOS）,probe into the mechanism and targets of Yishenyangyinhuoxue Chinese traditional medicine to reat PCOS,consequently providing the new method for the therapy of Chinese traditional medicine.Method Adopting Yishenyangyinhuoxue method,drawing Yishenyangyinhuoxue recipe,and making use of the combination of experimental and clinical research,we are expecting to open out the key of Yishenyangyinhuoxue medicine to treat PCOS by observing the change of PCOS correlative hormones、INH-B、ACT-A、rats exfoliated cells vaginal smear and the changes of PCOS heterogeneous symptom and ovarian local form.Results The experimental research indicates that Yishenyangyinhuoxue recipe can raise the uterus modulus of the rat of polycystic ovary pathological model,lower the ovary modulus,decrease T、LH、LH/FSH、INS、GS、INH-B and increase FSH and ACT-A in serum,improve the ovarian pathology of the rat of polycystic ovary pathological model, promote the resumption of the estrous cycle.The clinical research indicates Yishenyangyinhuoxue recipe can decrease T、LH、LH/FSH、INS and increase FSH、E₂ in serum of PCOS,and improve PCOS patients with acne and other abnormal signs.Conclusions Yishenyangyinhuoxue recipe was proved efficient in healing PCOS, which break through the routine thoughtway of Wenshenzhuyang and indicate that shenyinbuzu yuxueneizu is the pathological characteristic of PCOS.Follicular mature obstacles and anovulatory is the core of reproductive dysfunction of PCOS. Yishenyangyinhuoxue recipe can promote the mature of follicles and ovulation,improve symptoms and regulate endocrine of PCOS patients,change the polycystic ovarian of pathology by regulating the HPOA and ovary local regulation factors.