| Objectives The purpose of this study was to investigate the risk factors,angiographic findings and the characteristics of premature coronary heart disease patients,and to further explore the relationship between premature coronary artery disease with homocysteine, C reactive protein, and the Gal-3 in order to provide a reference value for clinical diagnosis and treatment.Methods From November 2014 to November 2015, in the Department of Cardiology of the Affiliated Hospital of North China University of science and technology of China,207 patients with stable angina or acute coronary syndrome were diagnosed with coronary angiography were chosen. According to the age,patients were divided into premature CHD group(male age < 55 years, female <65years)and late-onset CHD(male age >55 years, female >65years). The general situation investigation, past medical history investigation and physical examination were carried out, and the clinical data and serum biochemical parameters, hs-CRP,Gal-3 and Hcy were analyzed and compared.Results 1 Smoking(premature CHD group 42.7% vs late CHD group was 28.8%;P = 0.037), family history of coronary heart disease(premature CHD group 34.0%vs late CHD group was 14.4%; P = 0.001), BMI(premature CHD group 64.4% vs late CHD group 51.5%; P=0.041), hypercholesterolemia(premature CHD group was 5.28±1.32 mmol/L vs late CHD group for 483±1.16 mmol/L; P = 0.041),hypertriglyceridemia(premature CHD group is 2.31 ± 2.07 mmol/L vs late CHD group was 1.65 ± 1.14 mmol/L; P = 0.005) in premature coronary heart disease group is more popular, type 2 diabetes(premature CHD group was 14.6% vs late CHD group was 26.9%; P = 0.039) and hypertension(premature CHD group was50.5% vs late CHD group was 64.4%; P = 0.049) have higher incidence in late CHD.2 Galectin-3(Gal-3)(premature CHD group was 6.89 + 2.88 ug/L vs late CHD group was 6.07±2.06 ug/L; P = 0.021), homocysteine(Hcy)(premature CHD group was 12.9±5.7 umol/L vs late coronary heart disease group for11.0±5.9 umol/L;P = 0.020) and high-sensitivity C-reactive protein(hs-CRP)(premature CHD group6.5±4.9 mg/L vs late CHD group for 4.9±4.3 mg/L; P = 0.015) in premature CHD increased significantly. 3 To develop early onset CHD was statistically significant indicator of multiariable Logistic regression analysis, Hcy:(OR=3.089, 1.322 ~7.217 95%CI), Gal-3:(OR=2.517, 1.206 ~ 5.250 95%CI), high blood pressure(OR=0.489, 0.251 ~ 0.952 95%CI), comparing differences between groups with statistical significance(P < 0.05). 4 The incidence of acute coronary syndrome in patients with premature coronary heart disease was significantly higher than that of late onset coronary heart disease(early onset CHD was 25.2% vs, late onset 13.4%;P=0.036). In the early onset of coronary heart disease group, single vessel disease has the advantage, the corresponding multiple vascular lesions in the late onset of the coronary heart disease group occupied the dominant position(premature CHD65% vs late onset CHD was 40.4%; P < 0.001).Conclusions 1 smoking, obesity, gender, family history of dyslipidemia and coronary heart disease is more common in premature coronary artery disease, and diabetes, hypertension is more common in late coronary heart disease. 2 Early onset coronary heart disease associated with Hcy, Gal- 3, high blood pressure.3 premature coronary artery disease with single-vessel disease and late coronary heart disease based multi-vessel disease mainly premature coronary heart disease in late onset CHD ACS manner common, late-onset coronary heart disease places SAP onset is more common. |
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