Maternal Exposure To Fine Particulate Matter (PM2.5) And Fetal Growth And Develop Ment:A Meta-analysis

Objective:Synthetically quantify the association between materna l exposure to PM2.5 during pregnancy and fetal growth and develop ment(FGR/SGA,LBW).Method:An online research via Medical Periodical Database of Medicine Information System, Conference Papers, Dissertations Digital Library, VIP Database for Chinese Technical Periodicals, Chinese Na tional Knowledge Infrastructure(CNKI),Pub Med/Medline was conducted using keywords “PM2.5” and “FGR”,“SGA”, “LBW”, combining ma nual searching in relevant journals for studies published from 1 Janua ry 2005 to 31 January 2016 met the above requirements. Perform me ta-analysis by Stata12.0 software. The between-study heterogeneity wa s assessed using the Chi-square-based Q statistic, then a fixed or ran dom effect model combining effect values was used to perform sensit ivity analysis and adjust publication bias.Result: In summary, there was no evidence of a statistically significant effect of a increase in PM2.5 exposure during the first trime ster pregnancy on the risk of FGR/SGA(OR=1.029,95%CI:0.979,1.083).A 3.2% increased risk of FGR/SGA(OR= 1.032,95%CI:1.023,1.042) was associated with per 10μg/m3 increase in PM2.5 during th e entire pregnancy period. The pooled results indicated a significant positive association between the risk of LBW and maternal exposure to PM2.5(OR=1.038,95%CI:1.020,1.056) during the entire pregnan cy period.Conclusion:Based on the present meta-analysis, we conclude tha t maternal exposure to PM2.5 during entire pregnancy has an adverse impact on FGR/SGA, LBW, and a negative association between FG R/SGA and maternal exposure to PM2.5 during the first trimester.