The Value Of HbA1c Diagnostic T2DM In High-risk Groups In Xining

Objective Fasting plasma glucose(FPG), 2 hours postprandial blood glucose(2 hPG), glycosylated hemoglobin(HbA1c) in the diagnosis of type 2 diabetes mellitus(T2DM) in high-risk populations compared the advantages and disadvantages of and its sensitivity in xining region.Glycated hemoglobin(HbA1c), the cut-off value of diagnosis of T2 DM.Methods Through the inclusion criteria and exclusion criteria, collect the risk of diabetes in xining region,The object of study, 297 cases(male 192, female 105), men with an average age of 50.6 + /- 11.67 years old; Women with an average age of 56.93 + /- 9.85 years old,Research objects were impaired oral glucose tolerance test(OGTT),at the same time determination of glycosylated hemoglobin(HbA1c).Results(1)According to the WHO standard about T2 DM,The 297 cases,with T2 DM 192 cases, impaired glucose tolerance(IGT) 42 cases, 63 cases of normal glucose tolerance(NGT);(2)By painting receiver operating characteristic(ROC curve),the area under the curve:2hPG0.996(95%CI 0.988~1.000),FPG0.980(95%CI 0.966~0.995),HbA1c0.952(95%CI 0.927~0.977);(3)Analysis of roc curve: The best cut-off value of diagnosis of HbA1 c diagnosed T2 DM is 6.25%,sensitivity90.1%, specificity87.3%,positive predictive value95.6%,negative predictive value74.3%;Diagnosis of T2 DM when FPG ≥7.0mmol/L,sensitivity65.1%,specificity100%PPV100%,NPV48.5%;Diagnosis of T2 DM when 2hPG≥1.1mmol/L,ensitivity96.9%, specificity100%,positive predictive value100%,negative predictive value91.3%; Conclusions(1)Application of FPG diagnosed T2 DM is better than that of HbA1 c,but the higher the missed diagnosis.(2)The best cut-off value of diagnosis of HbA1 c diagnosed T2 DM is 6.25% in xining rejion;(3)Application of HbA1c≥6.25% in the diagnosis of diabetes is higher than the sensitivity of FPG≥7.0mmol/L, but similar to 2 hPG≥11.1mmol/L diagnostic sensitivity of T2 DM.