The Efficacy And Safety Of Lipid Emulsion In The Early Treatment Of Very Low Birth Weight Premature Infants: A Systematic Review

Objective To systematically evaluate the efficacy and safety of lipid emulsion in the early treatment of the very low birth weight premature infants.Methods The Pub Med, Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, OVID, Chinese biomedical literature database(CBM), CNKI, VIP, and Wan fang databases journals were searched up to March 2015 to collect the English and Chinese literature about randomized controlled trials(RCTs) of lipid emulsion in the early treatment of the very low birth weight premature infants. The reviewers screened the literature, extracted the data, and assessed the quality according to the method of Jadad′s Scale, and conducted Meta-analysis with Rev Man5.2 software.Results A total of 13 RCTs were included, including 852 patients( experimental group: 440 patients, control group: 412 patients). Meta-analysis showed that the recovery of birth weight in the experimental group was shorter than that in the control group[MD=-3.09,95%CI=-3.58 to-2.60,P<0.00001]. There was no significant differences in the incidence of necrotizing enterocolitis(NEC)(RR=0.66,95%CI= 0.33 to 1.32,P=0.24), sepsis(RR=0.85,95%CI= 0.72 to 1.00,P=0.05), jaundice(RR=1.03,95%CI= 0.84 to 1.25,P=0.78), mortality during hospitalization(RR=0.93,95%CI= 0.70 to 1.22,P=0.59), hypertriglyceridemia(RR=1.24,95%CI= 0.75 to 2.04,P=0.41), hypoglycemia(RR=1.55,95%CI= 0.82 to 2.92,P=0.17)and bronchopulmonary dysplasia(BPD)( RR=0.92,95%CI= 0.70 to 1.20,P=0.53) between two groups.Conclusion Early lipid emulsion(≤2d) is a safe and effective treatment for the very low birth weight premature infants, not only shortening the time of recovery of the birth weight, but not increasing the incidence of other adverse reactions.