| Objective To investigate the intolerance in preterm infants receving an early parenteral nutrition and whether the mode of delivery of parenteral fat emulsion influences lipid peroxidation. Aim at the safety and effectiveness of parenteral nutrition (PN) in very low birth weight infants.Methods Thirty cases of very low birth weight neonates were randomly divided into three groups :the preterm infants received pareneral nutrition containing amino acids+dextrose+Soluvit, (Group A,n=10) or light protected(Group B, n=10). In Group C(n=10), Soluvit and Vitlipid were co-administered with Intralipid and light protected. All the prematures received PN for seven days and we collected ten VLBWI not receiving PN as the control group.Anti-oxidation level,ascorbate,blood glucose,oxygen saturation,serum biochemistry index and body weight were determined before and after the experiment.Results 7 days after PN,the MDA concentrations in the test groups all increased (⊿dA is the most,⊿dB is the next,⊿dc is the least). For superoxidedimutase (SOD) reduction concentrations,⊿dA decreased sharply, then was⊿dB,⊿dc decreased little, The blood vitamin C increasion in group C was more than group A and group B. Significant changes of MDA,SOD and vitamin C existed among the group A,group B,group C and the control group. No significant changes in blood biochemistry,oxygen saturations and blood glucose were found among the four groups.Conclusions Multivitamin preparations protect fat emulsion against light-induced formation of lipid hydroperoxides , and administering multivitamins with fat emulsion via dark delivery tubing provide a practical way of preventing peroxidation of the lipid while limiting vitamin loss. Furthermore, it is relatively safe to apply fat emulsion intravenously with suitable dose and infusion rate for a few days to very low birth weight infants from the 2nd day of birth who require partial parenteral nutrition. Chang Sufang(Pediatrics) Directed by Xu Chongmin... |
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