The Benefits And Risks Of Prophylactic Use Of Antiepileptic Drug Therapy In Patients With Brain Tumor-related Epilepsy

BackgroundBrain tumor-related epilepsy( BTE), that is due to the tumor itself or its placeholder effects lead to abnormal discharge phenomenon of lesions around the nerve cells and induce a series of clinical symptoms,including consciousness, physical activity, physical sensation and autonomic nerve system disorders, et al. And to all patients and families with far-reaching consequences. Clinically often use the treatment such as surgery, radiation and chemotherapy and antiepileptic drugs, is proposed to actively control the attacks of Brain tumor-related epilepsy and improve the quality of life. In the past,some studies showed that the patients with brain tumor of preventive application of antiepileptic drugs(AEDs) whether can reduce seizure incidence has been controversial, and no relevant guides or expert consensus be clear Brain tumor-related epilepsy patients whether should be routine given preventive therapy of antiepileptic drugs.ObjectiveAnalysis After prophylactic AEDs therapy, patients with brain tumors is that whether seizures will get benefits, as well as common adverse reactions of AEDs in clinical risk assessment.MethodsCollect the cases and follow-up data of patients with the diagnosis of brain tumors in our hospital(the second affiliated hospital of chongqing medical university) in June 2011 to February 2015. Through the strict inclusion criteria and exclusion criteria review, the standard patients were divided into two groups: treatment group and control group, and compared two groups of patients in the incidence of epilepsy and seizure frequency,and observe the adverse reactions after the use of AEDs, and then analyzed the outcome of patients with brain tumors in short term and long term by SPSS software.ResultsThrough the strict inclusion criteria and exclusion criteria, a total of 68 cases were included.The analysis showed that prophylactic use of AEDs in 3 months, the treatment group and the control group in the incidence of epilepsy seizures were 14.6% and 37.5%; At 12 months, patients oftreatment group and control group of epileptic seizures in seizure frequency≥3 times were respectively 26.7% and 75%. By χ2 test, two sets of data has a significant difference. All preventive medicine in patients, however, a few patients experiencing discomfort, and no serious adverse reaction of patients.ConclusionFor the treatment of patients with brain tumors prophylactic AEDs benefits outweigh the risks:(1) Patients with prophylactic use of AEDs after treatment overall adverse reaction risk is relatively small.(2) In patients with brain tumors can significantly reduce the incidence of epilepsy in the short-term curative effect, so it can be one step closer to patients treatment provides a relatively stable time window, can reduce or prevent seizures caused by brain damage.(3) Although the long-term efficacy of brain tumor patients did not have a reduction in the incidence of epileptic seizures, but can significantly reduce the frequency of seizures, it can also improve the long-term quality of life.